Correlation between enhancement characteristics of MR mammography and capillary density of breast lesions |
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| Affiliation: | 1. Charité, Universitätsmedizin Berlin, Department of Radiology, Augustenburger Platz 1, 13353 Berlin, Germany;2. Universitätsklinikum Bonn, Department of Pathology, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany;3. Institut für Histologie und Zytologie, Bahnhofplatz 11, Postfach, 9101 Herisau, Switzerland;4. Diagnostik Ernst von Bergmann GmbH, Charlottenstr. 72, 14467 Potsdam, Germany;1. Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan;2. Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan;3. Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan;4. Toshiba Medical Systems Corporation, 1385 Shimoishigami, Otawara, Tochigi 324-8550, Japan;1. Department of Radiology, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, United States;2. Siemens AG, Healthcare Sector, Erlangen, Germany;1. Lanthio Pharma, a MorphoSys AG company, 9727 DL, Groningen, the Netherlands;2. Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG, Groningen, the Netherlands;3. Constant Pharmaceuticals LLC, 398 Columbus Ave, PMB 507, Boston, MA, 02116, USA;1. Department of Radiology, Ehime University Graduate School of Medicine, Japan;2. Department of Cardiovascular Internal Medicine, Ehime University Graduate School of Medicine, Japan;1. Department of Geriatrics, Slotervaart Hospital, Amsterdam, The Netherlands;2. Department of Internal Medicine, Spaarne Hospital, Hoofddorp, The Netherlands;3. Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands;4. Department of Geriatrics, Gelre Hospitals, Apeldoorn, The Netherlands;5. Department of Radiology, Slotervaart Hospital, Amsterdam, The Netherlands;6. Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands;1. Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari – Polo di Monserrato, s.s. 554 Monserrato, Cagliari 09045, Italy;2. Department of Radiology, Azienda Ospedaliero Brotzu (A.O.B.), di Cagliari, Cagliari 09100, Italy;3. Department of Radiology, New York University School of Medicine, New York, USA;4. Department of Neurology and Psychiatry, Sapienza University of Rome, Italy;5. Department of Vascular Surgery, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari – Polo di Monserrato, s.s. 554 Monserrato, Cagliari 09045, Italy;6. Diagnostic and Monitoring Division, AtheroPointTM LLC, Roseville, CA, USA;7. Electrical Engineering Department (Aff.), Idaho State University, ID, USA;8. Department of Radiology, Neuroradiology Division, University of Virginia, Box 800170, Charlottesville, VA, 22908, USA |
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| Abstract: | ![]()
ObjectiveTo correlate capillary density of breast lesions using the markers D2-40, CD31, and CD34 with early and late enhancement of magnetic resonance mammography (MRM).Materials and methodsThe local ethics committee approved this study, and informed consent was available from all patients. The study included 64 women with 66 histologically proven breast lesions (41 malignant, 25 benign). MR-enhancement 1 min after contrast medium administration was determined in the tumor (It1/It0 ratio) and in comparison to the surrounding tissue (It1/It1-fat ratio). Capillary density was quantified based on immunohistological staining with D2-40, CD31, and CD34 in breast tumors and surrounding breast tissue. Mean capillary densities were correlated with contrast enhancement in the tumor and surrounding breast tissue. The Kruskal–Wallis test was used to test whether lesions with different MR enhancement patterns differed in terms of capillary density.ResultsFor CD34, there was statistically significant correlation between capillary density and tumor enhancement (r = 0.329, p = 0.012), however not for the malignant or benign groups separately. Mean vessel number identified by staining with D2-40 and CD31 did not correlate significantly with tumor enhancement (D2-40: r = −0.188, p = 0.130; CD31: r = 0.095, p = 0.448). There were no statistically significant differences in capillary density between breast lesions with delayed enhancement or a plateau and lesions showing washout (Kruskal–Wallis test. D2-40: p = 0.173; CD31: p = 0.647; CD34: p = 0.515).ConclusionOf the three markers tested, CD34 showed best correlation between early contrast enhancement on MRM and capillary density. Further studies are necessary to clearly demonstrate an association between capillary density and contrast enhancement in breast tumors and surrounding tissue. |
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| Keywords: | Magnetic resonance imaging Breast neoplasms Pathology Blood supply |
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