Age-related changes of the diffusion tensor imaging parameters of the normal cervical spinal cord |
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| Affiliation: | 1. Orthopedics Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, China;2. Radiology Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, China;1. Department of Radiology, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, United States;2. Siemens AG, Healthcare Sector, Erlangen, Germany;1. Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf, Germany;2. Univ Dusseldorf, Medical Faculty, Department of Urology, Moorenstr. 5, D-40225 Dusseldorf, Germany;1. Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto I, “Sapienza” University of Rome, Viale Regina Elena 315, 00161 Rome, Italy;2. Service de Radiologie et Imagerie Cardiovasculaire, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Avenue Oscar Lambret, 59037 Lille Cedex, France;3. Department of Cardiovascular, Respiratory, Nephrologic, Anestesiologic and Geriatric Sciences, Sapienza University of Rome, Policlinico Umberto I, Via del Policlinico 165, 00161 Rome, Rome, Italy;1. Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany;2. Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Germany;1. Department of Neurological Surgery, Nippon Medical School, Tamanagayama Hospital, Tokyoto, Japan;2. Department of Neurological Surgery, Nippon Medical School, Tokyoto, Japan |
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| Abstract: | ![]()
BackgroundThe diffusion tensor imaging (DTI) parameters of the cervical spinal cord (CSC) changes with age. However, previous studies only examined specific CSC areas.ObjectivesTo analyze the DTI parameters in all intervertebral space levels of the whole normal CSC and to study the impact of age on these parameters in a Chinese population.MethodsThirty-six healthy subjects aged 20–77 years were recruited. DTI parameters were calculated for gray matter (GM) and white matter (WM) funiculi in all the CSC intervertebral spaces (C1/2-C6/7). Age-related changes of DTI parameters were analyzed for the GM and WM funiculi.ResultsFractional anisotropy (FA) and mean diffusivity (MD) were lower in GM than in WM. MD and FA values were lower in the WM in the lower CSC compared with the upper CSC (all P < 0.05), but no difference was observed in GM. In ventral funiculi, MD increased with age, while FA decreased (all P < 0.001). In lateral and dorsal funiculi, MD and FA decreased with age (all P < 0.001). In GM, MD and FA decreased with age (all P < 0.001). Significant age-related changes were observed in FA and MD from GM and WM funiculi. FA was correlated with age in all funiculi (ventral: r = −0.733; lateral: r = −0.468; dorsal: r = −0.607; GM: r = −0.724; all P < 0.01).ConclusionImportant changes in MD and FA were observed with advancing age at all levels of CSC in Chinese patients. DTI parameters may be useful to assess CSC pathology, but the influence of age and segments need to be taken into account in diagnosis. |
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| Keywords: | Magnetic resonance imaging Cervical spinal cord Intervertebral space Diffusion tensor imaging Apparent diffusion coefficient Fractional anisotropy |
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