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| 肠源性内毒素移位后的体内分布 | |
| 引用本文： | 刘竞,崔乃强,赵琪,吴咸中. 肠源性内毒素移位后的体内分布[J]. 中国急救医学, 2000, 20(3): 146-147 |
| 作者姓名： | 刘竞 崔乃强 赵琪 吴咸中 |
| 作者单位： | 1. 北京解放军263医院,101149 2. 天津市中西医结合急腹症研究所 |
| 摘 要： | 探讨肠源性内毒素移位后在腹膜炎大鼠各脏器中分布。方法以＾１２５Ｉ－ＬＰＳ对大鼠灌胃后，检测各脏器单位组织重量中内毒素含量。结果腹膜炎组各主要脏器单位重量中的内毒素含量增加，由至低为肾、肺、肝、胰、肠系膜淋巴结，心脏。结论急性感染腹膜炎可致肠源性内毒素移位增加。 |
| 关 键 词： | 肠源性内毒素 体内分布 腹膜炎 细菌移位 |
| 文章编号： | 1002-1949(2000)03-0146-02 |
| 修稿时间： | 1999-03-29 |
Distribute of enterogenic endotoxin after translocation in vivo |
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| LIU Jing,CUI Nai-qiang,ZHAO Qi,et al.. Distribute of enterogenic endotoxin after translocation in vivo[J]. Chinese Journal of Critical Care Medicine, 2000, 20(3): 146-147 | |
| Authors: | LIU Jing CUI Nai-qiang ZHAO Qi et al. |
| Affiliation: | LIU Jing,CUI Nai-qiang,ZHAO Qi,et al .The 263rd Hospital of PLA,Beijing 101149,China [ |
| Abstract: | Objective To study the distribution of enterogenic endotoxin in peritonitised rats.Method The amount of 125 I-LPS in the unit weight of the each organ are detected. After 125 I-LPS was poured down the stomach of rats.Results Amount of endotoxin in main organs are increase in peritonitised rats ( P <0 05).The order from high to low is kidney ,liver ,lung ,pancreas ,spleen ,mesenterium lymph node ,heart ( P <0 05).Cefesulodin and PolymyxinB can significantly reduce the amount of 125 I-LPS.Conclusions acute infectious peritonitis can increase the translocation of enterogenic endtoxin .Renal failure and respiratory failure are related with the amount of endotoxin in the unit weight of organic tissue .Cefesulodin and PolymyxinB can significantly reduce the mortality and inhibite the translocation of enteroqenic endotoxin in peritonitised rats.[ |
| Keywords: | Enterogenic endotoxin Distribute Peritonitis |
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