浙江舟山群岛居民甲状腺功能亢进症患病情况调查

目的调查浙江舟山群岛各地区甲状腺功能亢进症(简称甲亢)患病情况及相关致病因素。方法对舟山海岛地区1389名城镇居民、502名农民、737名盐民、362名渔民及294名普陀山僧侣进行流行病学问卷调查、血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)和尿碘测定。8～10岁儿童仅行尿碘检测。结果舟山海岛地区城镇居民、农民、盐民、渔民及普陀山僧侣的尿碘中位数(MUI)分别为320.7μg/L、188.9μg/L、122.2μg/L、193.6μg/L and 271.7μg/L,临床甲亢和亚临床甲亢的患病率分别为0.50%、0.40%、0.41%、0.55%、0.34%和0.79%、0.80%、0.68%、0.83%、0.68%,女性较男性更易患甲亢,TPOAb阳性者患甲亢危险性较高(P<0.05)。结论舟山海岛地区碘营养充足,需警惕自身免疫性甲亢的发生。

Investigation of the Prevalence of Hyperthyroidism in Zhoushan Archipelago

Objective To investigate the prevalence of hyperthyroidism and explore its assosiated risk factors in various regions in Zhoushan archipelago.Methods All the residents in Zhoushan archipelago,including 1389 urban residents,737 salt-maked,362 fishers and 294 buddhist in Putuo Mountain,were surveyed by questionnaire and their serum thyroid stimulating hormone(TSH),free triiodothyronine 3(FT3),free thyroxine(FT4),thyroid peroxidase antibody(TPOAb) and urinary iodine were detected.Results The median levels of urinary iodine of urban residents,famers,salt-maked,fishers,buddhist were 320.7μg/L,188.9μg/L,122.2μg/L,193.6μg/L and 271.7μg/L respectively,while the prevalence rates of hyperthyroidism and subclinical hyperthyroidism were 0.50%,0.40%,0.41%,0.55%,0.34% and 0.79%,0.80%,0.68%,0.83%,0.68%,respectively;Female and the TPOAB-positive had the higher risk of hyperthyroidism(P<0.05).Conclusion The residents of ZhouShan Archipelago had an adequate iodine in-take,so that they should be aware of higher incidence of autoimmune hyperthyroidismand.