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| 正交试验法筛选活血通络巴布膏的基质处方 | |
| 引用本文： | 曾超. 正交试验法筛选活血通络巴布膏的基质处方[J]. 药学实践杂志, 2012, 30(5): 348-350 |
| 作者姓名： | 曾超 |
| 作者单位： | 浙江中医药大学附属第三医院 |
| 摘 要： | 目的筛选活血通络巴布膏的基质处方。方法采用正交试验法,以黏着力、剥离性、涂展性、膏体均匀性、皮肤追随性和赋形性为指标,各基质及其用量为因素和水平进行L16(45)试验,得出最优配比组成。结果基质最佳配比为水∶甘油∶聚丙烯酸钠(PAANa):羧甲基纤维素钠(CMC):聚乙烯吡咯烷酮(PVP)=6.0∶4.0∶1.6∶0.4∶0.3。结论筛选的基质处方经济实用可行,与活血通络药物有良好的相容性。 |
| 关 键 词： | 正交试验 活血通络巴布膏 基质处方 |
| 收稿时间： | 2012-02-18 |
| 修稿时间： | 2012-03-27 |
Optimization of the matrix formulation of Huoxuetongluo cataplasmata by orthogonal design |
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| ZENG Chao. Optimization of the matrix formulation of Huoxuetongluo cataplasmata by orthogonal design[J]. The Journal of Pharmaceutical Practice, 2012, 30(5): 348-350 | |
| Authors: | ZENG Chao |
| Affiliation: | ZENG Chao(Third Hospital Affiliated to Zhejiang University of TCM,Hangzhou 310053,China) |
| Abstract: | Objective To optimize the matrix formulation of Huoxuetongluo cataplasmata.Methods The optimal preparation was selected by L16(45) orthogonal design.The adhering potential,fissility,ability to spread out,homogeneity,ability pasting to skin and recontourity were used as indexes.Results The optimal matrix formulation was water:glycerine:gelatin:sodium polyacrylate:sodium carboxymethycellulose: polyvinylpyrrolidone = 6.0:4.0:1.6:0.4:0.3.Conclusion The optimal matrix formulation was practical and economical which was compatible with Huoxuetongluo medicine. |
| Keywords: | orthogonal design Huoxuetongluo cataplasmata matrix |
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