糖尿病视网膜病患者外周血25羟基维生素D的测定及临床意义

目的探讨糖尿病视网膜病(DR)患者与外周血25羟基维生素D的关系。方法将114名病人分成3组,非糖尿病组33,糖尿病无视网膜病变组37,糖尿病视网膜病变组44,采用酶联免疫吸附法(ELISA)测定外周血25羟基维生素D水平。结果 DR患者外周血25羟基维生素D与糖尿病组及对照组比较差异有显著性(P<0.05),糖尿病组与对照组比较亦有差异(P<0.05)。结论 25羟基维生素D在DR患者外周血中明显降低,它在糖尿病视网膜疾病的发生发展中有重要的作用。

To Detetion of Serum 25-hydroxyvitamin D in Diabetes Retinopathy Subjects and Its Clinical Significance

Objective To discuss the relationship between diabetes retinopathy(DR)patients and serum 25-hydroxyvitamin D.Methods A total of 114 patients were divided into three groups,no diabetes group(n=33),diabets with no diabetic retinopathy group(n=37),diabetid retinopathy group(n=44).The 25-hydroxyvitamin D levels in serum samples were mesured by enzyme-linked imminosorbent assay(ELISA).Results DR subjects had lower 25-hydroxyvitamin D levels than the other groups,and the difference was significant(P<0.05).Diabetes group had lower 25-hydroxyvitamin D levels than no diabetes group,and the difference was significant(P<0.05).Conclusion This study suggests that diabetes subjectd,especially those with diabetes retinopathy(DR),have lower 25-hydroxyvitamin D levels than those without diabeted.25-hydroxyvitamin D levels plays an important role in the devepment of diabetes retinopathy.