广西汉族人群高血压与瞬时受体电位香草酸亚型1基因多态性/单倍型相关性病例对照研究

目的:分析瞬时受体电位香草酸亚型1(transient receptor potential family vanilloid subtype 1,TRPV1)基因多态性/单倍型与广西地区汉族人群高血压关系,为高血压防控提供依据。方法:以本院心血管内科住院及门诊的汉族高血压患者为病例组,选取本院体检科性别相同、年龄±5岁的汉族成年健康体检者为对照组,对两组人群TRPV1基因8个位点(rs17706630、rs222747、rs222749、rs224534、rs4790521、rs4790522、rs8065080、rs9894618)进行基因分型,并通过SHEsis PL在线平台确定其单倍型。结果:rs8065080位点T等位基因频率病例组高于对照组,两组基因型频率分布相当。两组人群TRPV1基因的rs17706630、rs222747、rs222749、rs224534、rs4790522等5个位点基因型频率和等位基因频率差别无统计学意义。5个位点主要构成7种单倍型,但在两组间分布差别均无统计学意义。结论:尚不能认为广西汉族人群TRPV1基因8个位点(rs17706630、rs222747、rs222749、rs224534、rs4790521、rs4790522、rs8065080、rs9894618)基因型与高血压易感性相关,但部分单倍型可能与高血压易感性有关,需要进一步研究确定。

A case-control study on the association between TRPV1 genetic polymor-phism and haplotype with hypertension in Guangxi Han nationality

Objective:To study the association between TRPV1 genetic polymorphism(SNPs) and haplotype with Hypertension in Guangxi Han nationality,and to provide the basis for the prevention and control of hypertension.Methods:Genotypes of single nucle-otide polymorphism of TRPV1 gene rs17706630,rs222747,rs222749,rs224534,rs4790521,rs4790522,rs8065080 and rs9894618 were detected in hypertension patients and age and gender matched healthy control individuals,and the haplotypes were analyzed by the SHEsis online platform.Results:Compared with control subjects,T allele frequency of loci rs8065080 hypertension patients was higher, there was no significant difference in allele frequency,genotype and haplotype distribution between hypertension patients and control subjects in other 5 locus.The 5 locus were mainly composed of 7 haplotype.Conclusion:We haven't found TRPV1 genotype is associ-ated with hypertension in Guangxi Han population,but some haploitypes may be associated with hypertension,need further study to de-termine.