肿瘤血管状况与宫颈癌放疗敏感性关系的临床探讨

目地：探讨肿瘤血管状况与宫颈癌放疗敏感性关系及临床应用价值。方法：用彩色多普勒血流显像（CDFI）评估放疗前肿瘤血管状况，主要指标为定量测定肿瘤血管阻力指数（RI）；肿瘤血管搏动指数（PI）并观察放疗后肿瘤消退结果。结果：30例宫颈癌患者21例放疗后为完全反应，9例为部分反应，完全反应组平均肿瘤血管阻力指数RI（0．61）高于部分反应组（0．39）（P〈0．01），完全反应组平均肿瘤血管搏动指数PI（1．21）高于部份反应组（0．62）（P〈0．01）。结论：宫颈癌血管生成活性与乏氧细胞活性及放疗敏感性密切相关，通过CDFI分析肿瘤血管状况来评价肿瘤氧合情况，肿瘤血管阻力指数RI和搏动指数PI与放射敏感性呈正相关，可指导宫颈癌放疗及预测放疗效果。

Discussion on tumour blood vessel condition and cervical cancer radiotherapy sensitivity

Objective： Discussion tumor blood vessel condition and cervical cancer radiotherapy sensitive relation and clinical practice value. Methods： （CDFI） appraises the radiotherapy before the colored Doppler blood stream developing the tumor blood vessel condition, major targets or quotas for quantitative determination of tumor blood vessel drag index RI; After tumor blood vessel putsation index PI and observes the radiotherapy, the tumor retrogression result, the tumor abates completely to respond completely that the tumor reduces 50% for the partial response. Result：after 30 example cervical cancer patient 21 example radiotherapies, to respond completely that 9 examples responded for the part, in the group with complete response,the average tumor blood vessel drag index RI （0.61） is higher than partial response group （0.39） （P 〈0.01 ） Complete response group average tumor blood vessel putsation index PI （ 1.21 ） is higher than partial response group （0.62） （P 〈 0. 01 ）. Conclusion： Cervical cancer blood vessel production activeness and deficiency oxygen cell activeness and pelvic cavity lymph node shift close related, appraises the tumor oxygenate situation through the CDFI analysis tumor blood vessel condition, tumor blood vessel drag index RI and putsation index PI and the emission sensitivity present is related, may instruct cervical cancer radiotherapy and the forecast radiotherapy effect.