直肠癌根治术后双重介入化疗的疗效分析

目的　探讨直肠癌根治术后双侧髂内动脉加门静脉灌注化疗的临床效果。方法　将 12 9例DukesB、C期直肠癌根治术患者随机分为两组 ,术后灌注化疗组 (A组 ) 69例 ,术后全身化疗组 (B组 ) 60例 ,均行 5 -FU加MMC化疗方案。结果　术后 1年内两组在局部复发率、肝转移率、生存率等方面差异无显著性 (P >0 .0 5 ) ;但术后 3年在肝转移率、生存率方面A组明显优于B组 (P <0 .0 5 )。结论　直肠癌根治术后双重介入灌注化疗优于全身化疗。

The therapeutic effective analysis of the double intervening chemotherapy after radical operation for rectal carcinoma

Objective To investigate the clinical effectiveness of chemotherapy perfusing in the bilateral internal iliac artery and portal vein after the radical operation for rectal carcinoma. Methods 129 patients with rectal carcinoma (Dukes B and C)who had gone through radical operation were randomly divided into two groups: Group A, 69 cases with postoperative perfusion chemotherapy; and Group B, 60 cases with postoperative total chemotherapy. Both of the two groups were given 5-FU plus MMC chemotherapy regimen. Results There were no statistically significant differences between regional recurrent rate, metastasis rate of hepatocarcinoma and survival rate in these two groups within one year after the operation (P>0.05); but three years after the operation, the metastasis rate of hepatocarcinoma and the survival rate in Group A was superior to Group B (P<0.05). Conclusions The double intervening perfusion chemotherapy had better effectiveness than total chemotherapy after the radical operation for rectal carcinoma.