首页 | 本学科首页   官方微博 | 高级检索  
     


Occupational exposure to trichloroethylene and serum concentrations of IL‐6, IL‐10, and TNF‐alpha
Authors:Bryan A. Bassig  Luoping Zhang  Xiaojiang Tang  Roel Vermeulen  Min Shen  Martyn T. Smith  Chuangyi Qiu  Yichen Ge  Zhiying Ji  Boris Reiss  H. Dean Hosgood III  Songwang Liu  Rachel Bagni  Weihong Guo  Mark Purdue  Wei Hu  Fei Yue  Laiyu Li  Hanlin Huang  Nathaniel Rothman  Qing Lan
Affiliation:1. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, , Bethesda, Maryland;2. Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, , Berkeley, California;3. Guangdong Poison Control Center, , Guangzhou, China;4. Institute for Risk Assessment Sciences, University of Utrecht, , Utrecht, The Netherlands;5. Formerly of the University of Utrecht, , Utrecht, The Netherlands;6. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, , Bronx, New York;7. Qiaotou Hospital, , Dongguan, Guangdong, China;8. Protein Expression Laboratory, Advanced Technology Program, SAIC‐Frederick, Inc., National Cancer Institute, , Frederick, Maryland
Abstract:To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross‐sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL‐6, IL‐10, and TNF‐α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL‐10 in workers exposed to TCE was decreased by 70% (P = 0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL‐10 was >60% and statistically significant in workers exposed to <12 ppm as well as in workers with exposures ≥ 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL‐6 or TNF‐α were observed among workers exposed to TCE compared to unexposed controls. Given that IL‐10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans. Environ. Mol. Mutagen. 54:450–454, 2013. © 2013 Wiley Periodicals, Inc.
Keywords:trichloroethylene  immunotoxicity  IL‐10  TNF‐α    IL‐6  occupational exposure
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号