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Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice |
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| Authors: | Dong‐Dong Ren Michael Kelly Sun Myoung Kim Cynthia Mary Grimsley‐Myers Fang‐Lu Chi Ping Chen | |
| Affiliation: | 1. Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, , Shanghai, China;2. Department of Cell Biology, Emory University, , Atlanta, Georgia | |
| Abstract: | Results: We identified Testin as a Vangl2‐interacting protein through a 2‐hybrid screen with a cochlea cDNA library. Testin is enriched to cell–cell boundaries in the presence of Vangl2 in cultured cells. Genetic inactivation of Testin leads to abnormal hair cell orientation in the vestibule and cellular patterning defects in the cochlea. In addition, Testin genetically interacts with Vangl2 to regulate hair cell orientation in the cochlea and the opening of the vaginal tract. | |
| Keywords: | testin planar cell polarity vangl2 inner ear female reproductive tract hair cells | |