Bladder cancer and seroreactivity to BK,JC and Merkel cell polyomaviruses: The Spanish bladder cancer study |
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| Authors: | Claudia Robles Raphael Viscidi Nuria Malats Debra T Silverman Adonina Tardon Reina Garcia‐Closas Consol Serra Alfredo Carrato Jesús Herranz Josep Lloreta Nathaniel Rothman Francisco X. Real Silvia de Sanjose Manolis Kogevinas |
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| Affiliation: | 1. Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, , Barcelona, Spain;2. Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, , Baltimore, MD, 21287;3. Spanish National Cancer Research Centre (CNIO), Genetic and Molecular Epidemiology Group, , 28029 Madrid, Spain;4. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, , Bethesda, MD, 20892‐7192;5. Universidad de Oviedo, , 33006 Oviedo, Spain;6. CIBER Epidemiologia y Salud Pública (CIBERESP), , 08036 Barcelona, Spain;7. Hospital Universitario de Canarias, , 38320 La Laguna, Tenerife, Spain;8. Consorci Hospitalari Parc Taulí, , 08208 Sabadell, Spain;9. Hospital General Universitario de Elche, , 03203 Elche, Spain;10. Hospital Ramon y Cajal, , 28034 Madrid, Spain;11. Hospital del Mar Research Institute (IMIM), , 08003 Barcelona, Spain;12. Spanish National Cancer Research Centre (CNIO), Epithelial Carcinogenesis Group, , 28029 Madrid, Spain;13. Department of Experimental and Health Sciences, Universitat Pompeu Fabra, , 08003 Barcelona, Spain;14. National School of Public Health, , Athens, AL, 35611 Greece;15. Centre for Research in Environmental Epidemiology (CREAL), , 08003 Barcelona, Spain |
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| Abstract: | ![]()
An infectious etiology for bladder cancer has long been suspected. Merkel cell virus (MCV), BKV and JCV polyomaviruses are possible causative agents but data remain scarce. Therefore, we evaluated the seroresponse to these three polyomaviruses in association with bladder cancer risk. 1,135 incident bladder cancer subjects from five Spanish regions and 982 hospital controls matched by sex, age and region were included. 99% of cases were urothelial‐cell carcinomas. Antibody response against MCV, BKV and JCV was measured by enzyme immunoassay using Virus‐Like‐Particles. Our results show a similar seroprevalence in cases and controls : 64/60% for BKV, 83/82% for MCV and 87/83% for JCV. However, among seropositive subjects, higher median seroreactivities were observed in cases compared to controls for BKV (0.84 vs. 0.70, p‐value = 0.009) and MCV (1.81 vs. 0.65, p‐value < 0.001). Increased bladder cancer risk was observed for BKV (OR = 1.4, 95%CI 1.04–1.8) and for MCV (OR = 1.5, 95%CI 1.2–1.9), when comparing highest to lowest seroreactivity tertiles. The associations of BKV and MCV with bladder cancer were independent of each other and neither smoking status nor disease stage and grade modified them. Furthermore, no association was observed between seroresponse to JCV and bladder cancer. Therefore, we conclude that BKV and MCV polyomavirus infection could be related to an increased bladder cancer risk. |
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| Keywords: | seroepidemiology BK polyomavirus Merkel cell polyomavirus JCV polyomavirus and bladder cancer |
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