紫杉醇注射液治疗妇科恶性肿瘤临床观察

目的：探讨紫杉醇注射液治疗妇科恶性肿瘤的疗效。方法：采取分组对照的研究方法,观察紫杉醇注射液化疗联合应用顺铂与采用PAC及VBP方案治疗妇科恶性肿瘤的疗效。将88例恶性肿瘤患者随机分为治疗组和对照组各44例,治疗组化疗前6、12h预防性给予20mg地塞米松（口服）,使用紫杉醇注射液前30min静注;对照组表阿霉素40～60mg/m2静注,第1天。VBP方案静注长春新碱1.5mg/m2。结果：治疗组与对照组对不同病理类型妇科恶性肿瘤的缓解率有显著差异,子宫颈癌缓解率分别为75.00%、53.85%;卵巢癌缓解率分别为81.81%、50.00%;子宫内膜癌缓解率分别为60.00%、42.86%;绒毛膜癌缓解率分别为50.00%、42.86%,χ2值分别为3.622、3.493、3.975、4.014,P〈0.05,治疗组缓解率显著高于对照组,两组化疗结束后白细胞下降率,差异有统计学意义。结论：紫杉醇注射液治疗妇科恶性肿瘤疗效确切,值得临床推广应用。

Clinical observation of paclitaxel injection in the treatment of gynecological cancer

Objective： To investigate the therapeutic efficacy of paclitaxel injection in the treatment of gynecological cancer. Methods： The group control study, concept chatai factors and cisplatin combination chemotherapy used PAC and VBP in the treatment of gynecological cancer. 88 patients with gynecological cancer were randomly divided into treatment group and control group 44 cases in each. 6, 12 h before chemotherapy, the treatment group were given prophylactic dexamethasone 20 mg （oral）, 30 min before the intravenous use of paclitaxel injection; control group were given epirubicin 40-60 mg/m2 intravenously on the first day. VBP program intravenous vincristine 1.5 mg/m2. Results： The treatment group and control group showed significantly different response rates in the treatment of the different pathological types of gynecological malignancies. Remission rates of the treatment group and control group were respectively 75.00% and 53.85% for cervical cancer, 81.81% and 50.00% for ovarian cancer, 60.00% and 42.86% for endometrial cancer and 50.00% and 42.86% for choriocarcinoma, with χ2 being 3.622, 3.493, 3.975, 4.014 respectively and P0.05 for all the types. The treatment group were significantly higher in remission rate than control group. And decline in white blood cells after chemotherapy were also significantly different in the two groups. Conclusion： Paclitaxel injection is effective in the treatment of gynecological malignancies, thus is worthy of clinical application.