逐瘀通脉胶囊联合长春西汀对慢性脑供血不足患者颈动脉斑块的影响

目的：探讨逐瘀通脉胶囊联合长春西汀注射液对慢性脑供血不足患者颈动脉粥样硬化斑块的影响及调脂作用。方法：将180例慢性脑供血不足患者随机分为四组,A组41例患者采用常规用药（抗血小板、营养神经,脑细胞活化剂）治疗;B组43例患者在A组用药基础上口服逐瘀通脉胶囊;C组45例患者在A组用药基础上静脉输入长春西汀注射液;D组51例患者在A组用药基础上采用逐瘀通脉胶囊联合长春西汀注射液治疗。观察比较各组临床疗效。结果：D组总有效率为96.07%,显著高于A组（60.97%）、B组（72.09%）和C组（73.33%）,差异均有统计学意义（P〈0.05）;D组治疗后颈动脉内膜中层厚度（TMT）、颈动脉粥样硬化斑块较治疗前明显改善（P〈0.05）,且优于B组和C组（P〈0.05）,且血管事件减少差异有统计学意义（P〈0.05）。结论：逐瘀通脉胶囊联合长春西汀注射治疗慢性脑供血不足,能更好地改善症状,调节血脂;可以稳定和减少颈动脉粥样硬化斑块形成,预防血管事件发生,疗效优于单纯使用逐瘀通脉胶囊或长春西汀。

Influence of Zhuyu Tongmai Capsule Combined with Vinpocetine of Carotid Plaques in Patients with Chronic Cerebral Circulation Insufficiency

Objective：To investigate the joint capsules stasis tongmai vinpocetine injection on chronic cerebral insufficiency carotid atherosclerotic plaque effects and Lipid Metabolism.Methods：180 cases of chronic cerebral insufficiency were randomLy divided into four groups,A group of 41 patients were treated with conventional therapy（anti-platelet,nutrition,nerve,brain cell activator） treatment;B group,43 patients in Group A on the basis of oral medication stasis Tongmai Capsule;C group of 45 patients in Group A on the basis of intravenous drug vinpocetine injection;D group of 51 patients in group A drug based on the combined use of stasis Tongmai Capsule vinpocetine injection.Observe and compare the clinical efficacy of each group.Results：D group,the total effective rate was 96.07%,significantly higher than in group A（60.97%）,B group（72.09%） and group C（73.33%）,the differences were statistically significant（P0.05）;D group therapy carotid intima-media thickness（TMT） cholesterol,carotid artery atherosclerotic plaque than before treatment significantly improved（P0.05）,and better than group B and group C（P0.05）,and the difference was reduced vascular events statistically significant（P0.05）.Conclusion：Capsule combined with stasis tongmai vinpocetine injection therapy of chronic cerebral insufficiency,is able to improve the symptoms,regulate blood lipids,stabilize and reduce carotid atherosclerotic plaque formation,prevention of vascular events,more effective than simply use stasis tongmai capsules or vinpocetine.