腺嘌呤核苷酸活化蛋白激酶与哺乳动物雷帕霉素靶蛋白信号转导通路的相互作用

背景：腺嘌呤核苷酸活化蛋白激酶的下游靶分子哺乳动物雷帕霉素靶蛋白对细胞生长、分裂和蛋白质合成有重要意义。目的：综述腺嘌呤核苷酸活化蛋白激酶与哺乳动物雷帕霉素靶蛋白信号转导相互调节的最新研究进展，以期揭示腺嘌呤核苷酸活化蛋白激酶和哺乳动物雷帕霉素靶蛋白信号转导的交互作用对蛋白质合成的影响。方法：以“(mammalian target of rapamycin OR mTOR) AND (AMP activated protein kinase OR AMPK) AND signal transduction”为检索式，计算机检索PubMed数据库相关内容的文献，最终纳入30篇可反映腺嘌呤核苷酸活化蛋白激酶与哺乳动物雷帕霉素靶蛋白信号转导通路相互作用的文献，并进行归纳总结。结果与结论：腺嘌呤核苷酸活化蛋白激酶活化导致哺乳动物雷帕霉素靶蛋白信号转导减弱一定程度上抑制蛋白质合成，腺嘌呤核苷酸活化蛋白激酶通过多个位点磷酸化和活化而调节哺乳动物雷帕霉素靶蛋白信号转导。腺嘌呤核苷酸活化蛋白激酶磷酸化马铃薯球蛋白会抑制Akt，ERK1/ERK2和p90rsk等其他蛋白激酶的作用。明确腺嘌呤核苷酸活化蛋白激酶对哺乳动物雷帕霉素靶蛋白的调节过程所起的作用，对揭示腺嘌呤核苷酸活化蛋白激酶-哺乳动物雷帕霉素靶蛋白途径调控能量代谢和蛋白合成方面有重要意义。

Interaction effects between AMP-activated protein kinase and mammalian target of rapamycin signaling pathways

BACKGROUND:The mammalian target of rapamycin (mTOR), a target protein of downstream AMP-activated protein kinase (AMPK), is a positive effector for cell growth, division and protein synthesis.OBJECTIVE:To summarize research progress concerning the regulation of mTOR signaling transduction by AMPK and the interaction effects of each other.METHODS:The author use the words of (mammalian target of rapamycin OR mTOR) AND (AMP activated protein kinase OR AMPK) AND signal transduction” by restriction fields of title/abstract in PubMed database. Totally 30 papers related to interaction effects of mTOR signaling transduction and AMPK were included.RESULTS AND CONCLUSION:AMPK activation reduces mTOR signal transduction, to some extent, inhibits protein synthesis. AMPK regulates mTOR signal transduction through phosphorylation and activation at multiple sites. AMPK phosphorylation of tuberin inhibits effective of Akt, ERK1/ERK2, and p90rsk the other protein kinases. In addition, clarify the regulation of AMPK on the mTOR plays an important role in revealing AMPK-mTOR passageways in controlling energy metabolism and protein synthesis.