^18F-FDG PET/CT在卵巢恶性肿瘤中的应用价值

目的：探讨PET/CT在卵巢恶性肿瘤术前评估及术后监测中的应用价值．方法回顾性分析接受18F-FDG PET/CT显像且临床病历资料完整的卵巢肿瘤病例45例，其中治疗前行PET/CT检查者10例，术后35例，临床随访时间至少6月．确诊依据为组织病理、临床随诊资料．结果（1） PET/CT诊断卵巢恶性肿瘤的灵敏度为94.6%，特异性为75.0%，诊断准确性为91.1%；（2）10例治疗前的卵巢肿瘤患者PET/CT均发现病灶，经术后病理证实2例为假阳性；（3）35例术后患者中2例（2/35）不规范手术后病例PET/CT发现病灶，33例（33/35）规范手术治疗后病例中6例（6/33）复查PET/CT未见病灶，4例（4/33） CA125及临床尚未见复发转移征象患者PET/CT发现复发转移病灶，且结果经术后病理或临床资料已证实．经病理或临床资料证实的23例复发转移且CA125升高患者，PET/CT结果显示21例有复发转移病灶．结论18F-FDG PET/CT在卵巢恶性肿瘤术前评估，术后复发或转移的早期诊断和准确定位中有重要作用，且能指导临床治疗．

Application Value of 18F-FDG PET/CT in Ovarian Cancer

Objective To evaluate the value of PET/CT in preoperative assessment and postoperative monitoring of ovarian cancer. Methods A retrospective analysis was conducted in 45 patients of ovarian neoplasm with clinical records underwent 18F-FDG PET/CT, including 10 patients underwent PET/CT before surgery and 35 patients after surgery. The clinical follow-up time was 6 months at least. The diagnosis based on pathology and clinical follow-up data. Results （1） The sensitivity, specificity and accuracy of PET/CT in detecting ovarian cancer were 94.6%,75.0%and 91.1%, respectively. （2） Ten patients before surgery were all detected tumor by PET/CT, but 2 of them were false positive based on pathologic results. （3） Two patients with non-standard surgery were detected tumor by PET/CT. In 33 patients after standard surgery, 6 patients were no tumor detected by PET/CT. In addition,4 patients with normal CA125 and no signs of recurrence and metastasis were detected tumor by PET/CT. The pathology and clinical follow-up data supported the results. 23 patients with higher CA125 were diagnosed recurrence and metastasis based on pathology and clinical follow-up data, 21 of them were detected tumor by PET/CT. Conclusion 18F-FDG PET/CT plays an important role in preoperative assessment, early diagnosis and accurate positioning of recurrent and metastasis of ovarian cancer. It can be used to guide the clinical treatment.