Twist在中晚期宫颈癌组织中的表达及临床意义研究

目的：研究Twist在中晚期宫颈癌组织中的表达及其与临床病理特征的关系，探讨Twist在宫颈癌侵袭、转移和进展中的作用．方法采用免疫组化法检测中、晚期宫颈癌组织微阵列芯片78例组织标本中Twist的表达情况；分析其表达与临床病理间的关系．结果（1）78例宫颈癌组织中 Twist的阳性表达率为56/78（71.8%）；（2） Twist在宫颈癌组织中表达与肿瘤组织学类型、FIGO分期、淋巴转移、分化程度密切相关，随着FIGO分期的变晚、淋巴转移的出现、分化程度的降低其表达逐渐增高（＜0.05）．结论 Twist在宫颈癌组织中表达可能与宫颈癌的侵袭、转移和进展密切相关．

Expression of Twist in Middle and Advanced Stages Cervical Cancer and Its Clinical Significance

Objective The purpose of this study was to research the expression of Twist in cervical cancer tissues and the relationship between its expression and clinicopathologic characteristic, and to investigate the role of twist in cervical cancer invasion, metastasis and progress. Methods Immunohistochemistry was used to detect the expression of the Twist in 78 cases of middle and advanced stages cervical cancer tissue microarray chip. The relationship between its expression and clinicopathological characteristic was analyzed. Results （1） The positive expression of twist in cervical cancer was 56/78 （71.8%）;（2） The expression of Twist in cervical cancer was significantly related to tumor histology type, FIGO stage, lymph node metastasis and differentiation degree. With the increase of FIGO stage, the emergence of lymph node metastasis and the decrease of differentiation degree, the expression of Twist increased gradually （P 〈0.05） . Conclusion The expression of Twist may be closely related to the invasion, metastasis and progress of cervial cancer.