1,2-二氯乙烷中毒糖皮质激素治疗后骨量减少与血脂、血钙相关性研究

目的 评估职业性急性1,2-二氯乙烷中毒患者应用糖皮质激素所致骨量减少与血脂、血钙的相关性。方法 选取某院2009年～2012年期间应用糖皮质激素治疗的职业性急性1,2-二氯乙烷中毒患者38例，采用双能X线骨密度仪测定相关部位的骨密度，记录低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（CHOL）、甘油三酯（TRIG）、血清总钙（TCa）等临床资料，资料录入和统计采用SPSS统计软件包。结果 LDL-C、CHOL、TCa对骨量存在影响（P＜0.05），而HDL-C、TRIG则对骨量无影响（P＞0.05）。结论 职业性急性1,2-二氯乙烷中毒患者应用糖皮质激素，可引起骨量减少或骨质疏松，严格控制血脂可能有助于减少骨量丢失。

Correlational study of the relationship among serum lipid, calcium, and osteopenia in patients after the treatment of 1,2-dichloroethane poisoning with glucocorticoids

Objective To evaluate the relationship among serum lipid, calcium, and osteopenia in patients after the treatment of occupational acute 1,2-dichloroethane poisoning with glucocorticoids. Methods A total of 38 patients, who had occupational acute 1,2-dichloroethane poisoning and received glucocorticoid treatment in our hospital from 2009 to 2012, were enrolled. Bone mineral density was detected using dual-energy X-ray absorptiometry. Clinical parameters including low density lipoprotein cholesterin (LDL-C), high density lipoprotein cholesterol (HDL-C), total cholesterol (CHOL), triglyceride (TRIG), and serum total calcium (TCa) were recorded. A SPSS 16.0 software was used for statistical analysis. Results The concentrations of LDL-C, CHOL, and TCa were correlated with osteopenia (P<0.05), whereas the concentrations of both HDL-C and TRIG showed no correlation with osteopenia (P>0.05). Conclusion The usage of glucocorticoids in patients with occupational acute 1,2-dichloroethane poisoning can cause osteopenia or osteoporosis. Strict control of serum lipid level may help preventing the loss of bone mass.