肝硬化患者幽门螺杆菌感染与血糖的关系

目的 :探讨肝硬化患者幽门螺杆菌 (HP)感染与血糖的关系。方法 :乙肝后肝硬化患者 14 0例 ,经检测HP后分HP阴性和阳性组 ,并设正常对照组 ,分别测定各组的空腹血糖 ;对于HP阳性病例根治HP后再次测定空腹血糖 ,并与根治前进行比较 ;同时 ,将HP阳性病例分为大量感染组、中量感染组及少量感染组 ,分别比较各组的空腹血糖 ;另外 ,对于HP阴性和阳性组病例 ,根据肝功能Child分级进行分组 ,分别比较各组的空腹血糖。结果 :HP阳性组血糖明显高于HP阴性组和对照组 (P <0 0 5 ) ;HP根治后血糖显著下降 (P <0 0 5 ) ,大量感染组明显高于少量感染组 (P <0 0 5 ) ;HP阳性组中肝功能ChildC、B级明显高于A级组 (P <0 0 5 ) ,而HP阴性组中各组之间无显著差异 (P >0 0 5 )。结论 :HP感染使肝硬化患者血糖升高 ,易于并发糖尿病 ,根治HP有利于防治肝性糖尿病。

Relationship between Helicobacter pylori Infection and Plasma Level of Glucose in Patients with Cirrhosis

Objective:To explore the relationship between Helicobacter pylori(HP) infection and the plasma level of glucose in patients with cirrhosis.Methods: 140 patients with cirrhosis after chronic hapatitis B were divided into HP infected group (HP group) and HP uninfected group (nHP group)after the HP test.A normal group of healthy people was set up as control. Then, the HP group was further divided into mild (mHP),midium (dHP),and severe (sHP)subgroups according to the severity degree of HP infection.And all the 140 cirrhosis patients were redivided into different grade groups (subgroups A,B,C)according to Child's system.The fasting blood glucose levels of each group were detemined. In HP group,the blood glucose level was re determined after the wholly treatment of HP.Results:The glucose level in HP group was significantly higher than those of nHP group and control group, and it decreased markedly after the wholly treatment of HP.The glucose level of sHP subgroup was singnificantly higher than that of mHP subgroup.In HP group,the glucose levels in subgroups B and C were singificantly higher than infection subgroup A. There was no significant difference among uninfected groups.Conclusion:HP infection could increase the blood glucose level of cirrhosis patients and make it easier for these patients to be attacked by diabetes.Curing HP is advantageous to the preventiong and curing of diabetes caused by liver disease.