| 溃疡性结肠炎患者血清NGAL检测及意义 |
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| 引用本文： | 李宝全,安翠平,赵小洁,陈正立,耿玉兰. 溃疡性结肠炎患者血清NGAL检测及意义[J]. 标记免疫分析与临床, 2015, 22(2): 113-115. DOI: 10.11748/bjmy.issn.1006-1703.2015.02.010 |
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| 作者姓名： | 李宝全 安翠平 赵小洁 陈正立 耿玉兰 |
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| 作者单位： | 石家庄市第一医院检验科,河北石家庄,050011;河北医科大学第一医院检验科,河北石家庄,050031 |
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| 摘 要： | 目的 探讨溃疡性结肠炎(UC)患者血液中NGAL的含量和意义.方法 使用胶乳增强免疫比浊法检测89例UC患者血清中NGAL含量并与对照组比较.分析NGAL水平与UC患者WBC数量、PLT数量、CRP和Hgb、HCT、ESR、年龄、疾病活动程度(DAI)关系.结果 UC患者血清中NGAL水平显著高于健康对照组,中位数分别为112ng/mL和48.2ng/mL,差异有统计学意义(P ＜0.0001).血清NGAL水平在轻度和中、重度UC患者血清NGAL中位数分别为78.2ng/mL和67.2ng/mL,差异有统计学意义(t=3.981,P=0.006).UC患者血清NGAL水平与WBC数量、PLT数量、CRP和Hgb、HCT、ESR、年龄无关(P＞0.05),与疾病活动程度(DAI)轻度相关(r=0.525,P＜0.0001).结论 溃疡性结肠炎患者血清NGAL水平升高,升高水平与疾病活动程度有关,但是其在疾病中的作用尚需进一步研究.
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| 关 键 词： | 溃疡性结肠炎 中性粒细胞明胶酶相关脂质蛋白 生物标志物 疾病活动程度 |
Clinical Significance of Serum Neutrophil Gelatinase-associated Lipocalin in Patients with Ulcerative Colitis |
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| LI Bao-quan,AN Cui-ping,ZHAO Xiao-jie,CHEN Zheng-li,GENG Yu-lan. Clinical Significance of Serum Neutrophil Gelatinase-associated Lipocalin in Patients with Ulcerative Colitis[J]. Labeled Immunoassays and Clinical Medicine, 2015, 22(2): 113-115. DOI: 10.11748/bjmy.issn.1006-1703.2015.02.010 |
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| Authors: | LI Bao-quan AN Cui-ping ZHAO Xiao-jie CHEN Zheng-li GENG Yu-lan |
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| Affiliation: | LI Bao-quan;AN Cui-ping;ZHAO Xiao-jie;CHEN Zheng-li;GENG Yu-lan;Department of Clinical Laboratory,The First Hospital of Shijiazhuang; |
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| Abstract: | |
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| Keywords: | Ulcerative colitis Neutrophil gelatinase-associated lipocalin Biomarker Disease activity index |
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