卡前列素治疗宫缩乏力性产后出血疗效观察

目的:观察卡前列素治疗宫缩乏力性产后出血的临床疗效。方法:选择经阴道及剖宫产分娩,因宫缩乏力,在胎儿娩出至产后2h失血量≥ 400ml的患者共64例,随机分为对照组和观察组各32例。在胎儿娩出后常规应用缩宫素20u子宫体肌肉注射,无效时对照组改用缩宫素20u静脉滴注,必要时重复使用,总量≤ 120u。观察组应用卡前列素250μg子宫体肌肉注射,必要时间隔15min重复使用,总量≤ 500μg。结果:观察组总有效率为93.75%,明显优于对照组的81.25%(P<0.01)。结论:卡前列素治疗宫缩乏力性产后出血的临床疗效显著,具有高效、迅速、副作用小、使用方便等优点,但应诊断明确,早期使用。

Efficacy of hemabate in treatment of postpartum hemorrhage due to uterine atony

Objective：To observe the effect of hemabate on patients with postpartum hemorrhage caused by uterine atony. Methods： Sixty-four patients with blood loss exceeding 400 ml within 2 hours after vaginal delivery or cesarean section due to uterine atony were randomly divide into control group and observation group. All the patients were routinely injected oxytocin 20 u to the uterine muscle after the baby was delivered . If the therapy did not work, the control group was given 20 u oxytocin intravenously, which might be repeated when necessary with a total volume ≤120 u ,while the observation group was administered injection of hemabate 250 μg into the uterine ,which might be repeated at 15 minutes intervals when necessary with a total volume ≤500μg. Results ：The total efficiency was 93.75 % in the observation group, which was superior to that of 81.25% in the control group （ P 〈 0.01 ）. Conclusions： Hemabate is effective on postpartum hemorrhage caused by uterine atony. It has the advantages of high efficiency, safity, light side effect and convenience. Correct diagnosis and early application are essential to achieve better results.