| 吗啡条件性位置偏爱大鼠脑伏核中CaMK Ⅱ及NOS阳性神经元变化 |
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| 引用本文： | 李峰,刘洋,焦莹,宋月晗,赵雪松,刘晓兰,刘燕.吗啡条件性位置偏爱大鼠脑伏核中CaMK Ⅱ及NOS阳性神经元变化[J].中国药物依赖性杂志,2008,17(5). |
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| 作者姓名： | 李峰 刘洋 焦莹 宋月晗 赵雪松 刘晓兰 刘燕 |
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| 作者单位： | 北京中医药大学,北京,100029 |
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| 基金项目： | 高等学校博士学科点专项科研项目 |
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| 摘 要： | 目的:研究吗啡条件性位置偏爱(CPP)大鼠伏核中CaMK Ⅱ及NOS的阳性神经元变化。方法:采用免疫组织化学实验方法观察CaMK Ⅱ及NOS阳性神经元的形态及数目的变化。结果:与正常对照组比较,吗啡模型组CaMK Ⅱ及NOS的阳性神经元数均明显升高(P<0.01)。结论:吗啡CPP大鼠伏核中显示CaMK Ⅱ及NOS的阳性神经元增多,参与了吗啡精神依赖的形成。
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| 关 键 词： | 精神依赖 吗啡 伏核 CaMK Ⅱ NOS 条件性位置偏爱 大鼠 |
THE CHANGES OF CaMK ⅡAND NOS POSITIVE NEURONS IN NUCLEUS ACCUMBENS OF RATS WITH MORPHINE INDUCED CONDITIONED PLACE PREFERENCE |
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| LI Feng,LIU Yang,JIAO Ying,SONG Yuehan,ZHAO Xuesong,LIU Xiaolan,LIU Yan.THE CHANGES OF CaMK ⅡAND NOS POSITIVE NEURONS IN NUCLEUS ACCUMBENS OF RATS WITH MORPHINE INDUCED CONDITIONED PLACE PREFERENCE[J].Chinese Journal of Drug Dependence,2008,17(5). |
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| Authors: | LI Feng LIU Yang JIAO Ying SONG Yuehan ZHAO Xuesong LIU Xiaolan LIU Yan |
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| Abstract: | Objective:To study changes of CaMK Ⅱ and NOS positive neurons in nucleus accumbens of rats with morphine-induced conditioned place preference(CPP). Methods:Using immunohistochemistry method to observe CaMK Ⅱ and NOS positive neurons' morphology and numbers. Results:CaMK Ⅱ and NOS positive neurons increased significantly(P<0.01)in morphine induced CPP rats compared with that in normal control group. Conclusion:The increased CaMK Ⅱ and NOS positive neurons in nucleus accumbens of morphine induced CPP rats involves in the formation of morphine psychological dependence. |
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| Keywords: | NOS |
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