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| 匹伐他汀治疗原发性高胆固醇血症的疗效与安全性评价 | |
| 引用本文： | 顾兴建,张亚文,吴宗贵. 匹伐他汀治疗原发性高胆固醇血症的疗效与安全性评价[J]. 世界临床药物, 2008, 29(10): 595-597 |
| 作者姓名： | 顾兴建 张亚文 吴宗贵 |
| 作者单位： | 第二军医大学附属长征医院心内科;第二军医大学附属长征医院心内科;第二军医大学附属长征医院心内科 |
| 摘 要： | 目的 评价匹伐他汀治疗原发性高胆固醇血症的疗效和安全性.方法 随机、单盲(对研究者设盲)、阳性药物平行对照.46例原发性高胆固醇血症患者随机分为匹伐他汀(2和4 mg)组和阿托伐他汀(10 mg)组,研究为期8周,观察治疗前后患者血脂[总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、甘油三酯(TG)]、丙氨酸氨基转移酶/天冬氨酸氨基转移酶(ALT/AST)及磷酸肌酸激酶(CPK)水平的变化.结果 治疗4和8周各组TC、LDL-C水平均明显降低(P<0.01), 且4周与8周无显著差异;治疗8周各组LDL-C达标率分别为62.5%、66.7%和86.7%;但3组HDL-C和TG水平治疗前后无明显变化.匹伐他汀(2 mg)组1例出现CPK水平异常升高,停药2周后恢复正常.结论 匹伐他汀能有效降低原发性高胆固醇血症患者的TC和LDL-C水平,疗效与阿托伐他汀相似,且基本安全. |
| 关 键 词： | 匹伐他汀 阿托伐他汀 高胆固醇血症 疗效 不良反应 |
Evaluation of the efficacy and safety of pitavastatin in treating primary hypercholesterolemia |
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| GU Xing-Jian,ZHANG Ya-Wen,WU Zong-Gui. Evaluation of the efficacy and safety of pitavastatin in treating primary hypercholesterolemia[J]. WORLD CLINICAL DRUGS, 2008, 29(10): 595-597 | |
| Authors: | GU Xing-Jian ZHANG Ya-Wen WU Zong-Gui |
| Affiliation: | GU Xing-Jian,ZHANG Ya-Wen,WU Zong-Gui (Department of Cardiology,Changzheng Hospital Affiliated to the Second Military Medical University,Shanghai 200003,China) |
| Abstract: | Objective To evaluate the clinical effect and safety of pitavastatin in the treatment of primary hypercholesterolemia. Methods A randomized,single-blind to investigator trial was conducted.46 patients with primary hypercholesterolemia were randomized into pitavastatin(2,4 mg) groups and atorvastatin(10 mg) group.The levels of total cholesterol (TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglycerides(TG),alanine aminotansferase/aspartate aminotransferase(ALT/A... |
| Keywords: | pitavastatin atorvastatin hypercholesterolemia effect adverse reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |