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| CEAE-cadherin表达与结直肠癌术后肝转移关系 | |
| 引用本文： | 李宁, 陈小兵, 万相斌, 罗素霞, 邹宏志, 韩黎丽. CEAE-cadherin表达与结直肠癌术后肝转移关系[J]. 中国肿瘤临床, 2008, 35(1): 36-38. |
| 作者姓名： | 李宁 陈小兵 万相斌 罗素霞 邹宏志 韩黎丽 |
| 作者单位： | 1.河南省肿瘤医院内科, 郑州市 450052;;2.郑州大学附属第一医院肿瘤中心;;3.河南省肿瘤医院普外科 |
| 基金项目： | 河南省医学科技创新人才工程基金资助（编号：200616） |
| 摘 要： | null |
| 关 键 词： | 结直肠癌 肝转移 E-cadherin CEA |
| 收稿时间： | 2007-08-14 |
| 修稿时间： | 2007-11-17 |
Expression of CEA and E-cadherin and Its Correlation with Liver Metastasis of Colorectal Cancer |
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| LI Ning, CHEN Xiaobing, WAN Xiangbin, LUO Suxia, ZHOU HongZhi, HAN Lili. Expression of CEA and E-cadherin and Its Correlation with Liver Metastasis of Colorectal Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(1): 36-38. | |
| Authors: | LI Ning CHEN Xiaobing WAN Xiangbin LUO Suxia ZHOU HongZhi HAN Lili |
| Affiliation: | 1.Department of Medical Oncology, He'nan Cancer Hospital, Zhengzhou 450008, China;;2.Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;;3.Department of General Surgery, He'nan Cancer Hospital, Zhengzhou 450008, China |
| Abstract: | Objective: To detect the expression of CEA and E-cadherin in the serum of patients with colorectal carcinoma and to investigate its correlation with liver metastasis. Methods: The serum of 60 patients (26 cases with liver metastasis and 34 cases without liver metastasis) with colorectal cancer was collected postoperatively. CEA level was evaluated by radioimmunoassay and E-cadherin was evaluated by immunohistochemistry. Results: In the 26 patients with liver metastasis, 24(24/26, 92.3%) presented with a high level of CEA, but only 9 of the 34 patients without liver metastasis were found to have a high level of CEA. The difference between the two groups was significant(P=0.004). Expression of E-cadherin was correlated with differentiation but was not correlated with T stage or N stage. The rate of liver metastasis was higher in patients with negative expression of E-cadherin than in patients with positive expression of E-cadherin. Survival analysis showed a significant difference in the occurrence of liver metastasis between the two groups (P<0.05). Conclusion: The expression of CEA and E-cadherin in the serum of patients with colorectal cancer can predict liver metastasis after surgery. |
| Keywords: | The expression of CEA and E-eadherin in the serum of patients with colorectal cancer can predict livermetastasis after surgery. |
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