多发性骨髓瘤骨病的诊断与治疗新进展

 约90 %的多发性骨髓瘤（MM）患者存在骨损害。常规X线检查只有在30 %的骨小梁缺失后才能发现溶骨性损害,对于初诊MM患者的分期,常规X线检查仍是"金标准"。在发现小的溶骨性病变方面CT扫描比常规X线检查更敏感,但对怀疑有椎体压迫的患者应行磁共振成像（MRI）或CT扫描。同位素骨扫描常常低估MM患者骨损害的程度。MM骨病的治疗包括双磷酸盐、新的靶向治疗、外科手术、放射治疗等治疗措施。

Diagnosis and treatment of bone disease of multiple myeloma

Up to 90 % of multiple myeloma patients can develop to osteolytic lesions. Although the conventional X radiography can only demonstrate the lytic bone disease when 30 % of the trabecular bone loss, it still remains the "gold standard" of the staging procedure of newly diagnosed myeloma patients. CT scans are more sensitive than X radiography for detecting small lytic lesions. MRI or CT is the choice of diagnosis to assess suspected cord compression. Technicium-99m bone scan in patients with myeloma usually underestimate the extent of bone damage. Treatments of myeloma bone disease include bisphosphonate therapy, novel targeted agents, surgical intervention and radiation therapy.