早期初诊帕金森病患者非运动症状的临床特征及影响因素分析

目的探讨早期帕金森病(PD)患者非运动症状(NMS)的临床特征及影响因素。方法收集门诊首次就诊且发病在1a内的早期PD患者105例和健康对照者100例,采用帕金森病非运动症状调查问卷(NMSQuest)进行NMS评估,结合临床特征等因素分析非运动症状发生的主要影响因素。结果 PD组NMS评分显著高于对照组(P0.05),发生率较高的症状依次为便秘(58例,55.2%)、记忆力下降(51例,48.6%)、情绪低落(43例,40.9%)。回归分析显示,H-Y分级、年龄及PD临床亚型是NMS评分的主要影响因素(P0.05),性别、文化程度、病程则与其无关。结论 NMS在早期PD患者中较常见且临床表现多样,需提高认识并及时干预。

Study on non-motor symptoms and their influencing factors in early stage newly diagnosed Parkinson's disease

Objective To explore the frequency of non-motor symptoms (NMS) and their influencing factors in a cohort of patients with newly diagnosed Parkinson's disease (PD).Methods A total of 105 patients with early PD and 100 healthy controls participated in this study.NMS were screened by the Nonmotor Symptom Questionnaire (NMSQuest),and their influencing factors were identified from clinical characteristics.Results The NMSQuest score in PD group was significantly higher than that of control group (P<0.05).In the PD group,the most commonly experienced NMS were constipation (58 cases,55.2%),memory deterioration (51 cases,48.6%),depressing emotion(43 cases,40.9%).Regression analysis showed that H-Y stage,age and PD subtype were influencing factors for NMSQuest score(P<0.05),but gender,education level and disease duration were not.Conclusion NMS in patients with newly diagnosed PD are common and diverse,so clinical doctors should be pay more attention to them and treat early.