阿托伐他汀联合尤瑞克林治疗急性脑梗死临床观察

目的探讨阿托伐他汀联合尤瑞克林对急性脑梗死患者脑血管储备能力(CVR)及神经功能的影响。方法选择2015-08—2016-08许昌县人民医院神经内科收治的急性脑梗死患者94例,随机分为2组各47例。2组均予以常规治疗,对照组在此基础上服用阿托伐他汀,观察组在对照组基础上加用尤瑞克林。比较2组CVR、神经功能、血清一氧化氮(NO)及血压水平。结果观察组CVR与血清NO水平均明显高于对照组,神经功能缺损评分明显低于对照组,差异均有统计学意义(P0.05);2组治疗前后血压水平均无明显变化,差异无统计学意义(P0.05)。结论阿托伐他汀联合尤瑞克林治疗急性脑梗死患者,可有效舒张血管,减少斑块破裂,提高脑血管储备能力,减轻神经功能缺损,具有应用价值。

Clinical observation of atorvastatin and urinary kallidinogenase in the treatment of patients with acute cerebral infarction

Objective To investigate the effect of atorvastatin and urinary kallidinogenase on eerebrovascular reserve (CVR) and nerve function in patients with acute cerebral infarction (ACI).Methods Ninety-four ACI patients treated in Department of Neurology,People's Hospital of Xuchang County were randomly divided into two groups,47 cases in each group.Two groups were given routine treatment;control group was also given atorvastatin,while observation group was given urinary kallidinogenase based on the control group.The CVR,nerve function,nitric oxide (NO) and level of blood pressure were compared between the two groups.Results The levels of CVR and NO in observation group were higher than those in control group,while the NIHSS was lower than control group (P＜0.05).Before and after treatment,the levels of blood pressure in two groups had no obvious changes,there was no statistical difference (P＞0.05).Conclusion Atorvastatin and urinary kallidinogenase in treatment of ACI can relax blood vessel,reduce plaque rupture,increase CVR,and decrease neurologic ischemia,which has application value.