急性脑梗死患者血液流变学及凝血功能的临床意义

目的探讨急性脑梗死患者血液流变学和凝血功能的变化及其临床意义。方法选择75例急性脑梗死为观察组,其中轻度、中度、重度各25例,选择同期75例健康体检者为对照组,比较2组血液流变学和凝血功能,记录观察组不同程度脑梗死患者的血液流变学和凝血功能。结果观察组全血高切黏度、全血低切黏度、血浆黏度和红细胞比积显著高于对照组(P0.05)。观察组血浆纤维蛋白原(FIB)明显高于对照组(P0.05),2组活化部分凝血活酶时间(APTT)和血浆凝血酶原时间(PT)比较差异无统计学意义(P0.05)。重度、中度和轻度患者的全血高切黏度、全血低切黏度、血浆黏度和红细胞比积比较差异有统计学意义(P0.05);重度、中度和轻度患者的FIB比较差异有统计学意义(P0.05)。结论急性脑梗死患者的血液流变学和凝血功能存在异常,且与病情严重程度成正比,监测其动态变化可为临床治疗提供参考价值。

Clinical significance of hemorheology and coagulation function in patients with acute cerebral infarction

Objective To investigate the changes and clinical significance of hemorheology and coagulation function in pa-tients with acute cerebral infarction.Methods Totally 75 cases of acute cerebral infarction were selected as the observation group, including 25 cases in mild,moderate and severe patients,respectively.Seventy-five healthy people were selected as the control group.Hemorheology and coagulation function were compared into two groups,and its changes were recorded in the observation group with different degree of cerebral infarction.Results Whole blood viscosity,whole blood low shear viscosity,plasma viscosity and hematocrit in the observation group were significantly higher than those in the control group (P <0.05 ).Plasma fibrinogen (FIB ) in the observation group were significantly higher than that in the control group (P < 0.05 ),activated partial thromboplastin time (APTT)and prothrombin time (PT)had no statistically significant difference in the two groups (P >0.05). There were statistically significant in high blood viscosity,low shear blood viscosity,plasma viscosity difference and hematocrit in severe,moderate and mild patients (P <0.05);there was statistically significant in FIB in severe,moderate and mild patients (P <0.05).Conclusion There are abnormal hemorheology and coagulation function in patients with acute cerebral infarction,and its changes are directly proportional to the severity of acute cerebral infarction.Monitoring the dynamic changes could provide refer-ence value for clinical treatment.