氯吡格雷联合阿司匹林治疗青年期急性非心源性脑梗死临床观察

目的观察氯吡格雷联合阿司匹林治疗青年急性脑梗死的疗效及不良反应。方法选择80例急性非心源性脑梗死的青年患者,随机分为观察组(n=40)和对照组(n=40)。观察组给予阿司匹林和氯吡格雷,对照组给予阿司匹林和安慰剂。根据卒中临床神经功能缺损评定标准(NIHSS)和日常生活能力(ADL)评分标准进行评定,并监测血清hs-CRP水平。结果治疗后21d,观察组NIHSS、ADL评分均明显优于对照组,观察组有效率显著好于对照组,hs-CRP水平明显降低,差异均有统计学意义(P0.05),且不良反应可耐受。结论氯吡格雷联合阿司匹林能明显改善急性非心源性脑梗死青年患者的预后,且较安全,有进一步研究的价值。

Clinical observation of clopidogrel and aspirin in the treatment of cerebral infarction in the youth

Objective To investigate the effects and adverse reactions of clopidogrel combined aspirin for cerebral infarction in the youth.Methods Eighty young patients with acute cerebral infarction were randomly divided into two groups,treatment group (n=40) was given clopidogrel and aspirin for 21 days,while control group (n=40) was given aspirin for 21 days.NIHSS/ADL evaluation and serum hs-CRP level were monitored before and after the treatment.Results Twenty-one days after the treatment,the ADL score in treatment group was significantly higher than that of control group,while NIHSS score and serum hs-CRP level were significantly lower(P<0.05),but no significant adverse effects were found.Conclusion Clopidogrel combined aspirin could significantly reduce neurological deficits without significant adverse effect,but more research was required.