| The Relation Between Hypertrophied Myocardium and Ventricular Fibrillation Threshold in Spontaneously Hypertensive Rats |
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| 引用本文： | 黄至斌 伍卫 邓义军 方昶 韦育林 周淑娴 王景峰. The Relation Between Hypertrophied Myocardium and Ventricular Fibrillation Threshold in Spontaneously Hypertensive Rats[J]. 岭南心血管病杂志(英文版), 2006, 7(1): 5-9 |
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| 作者姓名： | 黄至斌 伍卫 邓义军 方昶 韦育林 周淑娴 王景峰 |
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| 作者单位： | Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University，Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University，Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University，Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University，Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University，Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University，Department of Cardiology The Second Affiliated Hospital of Sun Yat-sen University Guangzhou 510120，China，Guangzhou 510120，China，Guangzhou 510120，China，Guangzhou 510120，China，Guangzhou 510120，China，Guangzhou 510120，China，Guangzhou 510120，China |
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| 摘 要： | Objectives To investigate the relation between hypertrophied myocardium and ventricular fibrillation threshold in spontaneously hypertensive rats (SHR). Methods 20 male SHR were randomly divided into two groups; 10 week group (n = 10) and 18 week group (n=10). 10 week male Wistar rats were controlled group (n=10). The systolic blood pressure (SBP), heart mass index (HMI), ventricular effective refractory period (VERP) and ventricular fibrillation threshold(VFT) were measured respectively. Results①The SBP and HMI of SHR were significantly higher than those of Wistar rats(P < 0.001). The VFT of SHR were significantly lower than that of Wistar rats (P < 0.001).②In SHR, the SBP and HMI of 18 week SHR were significantly higher than those of 10 week SHR (P< 0.001). The VFT of 18 week SHR were significantly lower than that of 10 week SHR (P < 0.001).③There were no significant difference of VERP among 10 week SHR, 18 week SHR and Wistar rats(P > 0.05).④There was no relationship between HMI and VFT or SBP in Wistar rats. There was significant relationship between HMI and VFT or SBP in different age spontaneously hypertensive rats.⑤HMI, age and species of animal were the major influent factors of VFT. Conclusions The VFT of hypertrophied myocardium decreased. The higher the degree of hypertrophy of myocardium and the higher the systolic blood pressure were, the lower the ventricular fibrillation threshold was.
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| 关 键 词： | 心肌肥大 心室疾病 高血压 治疗 |
The Relation Between Hypertrophied Myocardium and Ventricular Fibrillation Threshold in Spontaneously Hypertensive Rats |
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| Huang Zhibin, Wu Wei, Deng Yijun, Fang Chang, Wei Yulin, Zhou Shuxian, Wang Jingfeng. The Relation Between Hypertrophied Myocardium and Ventricular Fibrillation Threshold in Spontaneously Hypertensive Rats[J]. South China Journal of Cardiology, 2006, 7(1): 5-9 |
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| Authors: | Huang Zhibin Wu Wei Deng Yijun Fang Chang Wei Yulin Zhou Shuxian Wang Jingfeng |
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| Affiliation: | Department of Cardiology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China |
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| Abstract: | |
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| Keywords: | Hypertrophied myocardium Electrophysiology Ventricular fibrillation threshold |
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