探讨中药黄芪多糖对溃疡性结肠炎大鼠肠道菌群失调的调整作用

目的:探讨中药黄芪多糖对溃疡性结肠炎大鼠肠道菌群失调的调整作用。方法:采用TNBS/乙醇液法建立溃疡性结肠炎大鼠模型,用黄芪多糖进行调整性治疗,针对治疗前后大鼠肠道菌群、肠道内乙酸含量、肝脏细菌易位数量进行检测并对结果进行统计学比较。结果:应用TNBS/乙醇液法建立溃疡性结肠炎大鼠模型是成功的,黄芪多糖对溃疡性结肠炎大鼠肠道微生态失调具有很好的调整作用,黄芪多糖治疗7 d后,大鼠肠道内双歧杆菌、乳酸杆菌含量明显上升,肠球菌、肠杆菌含量下降,大鼠肠道菌群比例恢复正常,大鼠结肠内挥发性脂肪酸的含量升高,肝脏细菌易位得到有效地控制。结论:黄芪多糖具有调整肠道微生态失调的作用,是理想的微生态调节剂,而且其作用优于丽珠肠乐。

Explore the Regulative Action of Astragalus Polysaccharide for Intestinal Dysbacteriosis in Ulcerative Colitis Rat Models

Objective: Explore the regulative action of astragalus polysaccharide for intestinal dysbacteriosis in ulcerative colitis rat models. Methods:TNBS/ethanol liquid used to establish ulcerative colitis rat models,then rats were treated with astragalus polysaccharide.We tested intestinal flora and acetic acid,liver bacterial translocation between pre and post treatment,then had a statistical analysis.Results: Using TNBS/ethanol liquid to establish ulcerative colitis rat models was successful.astragalus polysaccharide could give a very effective adjustment for intestinal micro-ecological imbalance in ulcerative colitis rats.astragalus polysaccharide treatment 7 days later,bifidobacterium and lactobacillus were increased remarkably,while enterococcus and enterobacter were decreased markedly.Intestinal flora proportion was recovered to the normal level.Acetic acid was increased greatly,and liver bacterial translocation was in effective control.Conclusion : Astragalus polysaccharide with the regulative action for intestinal dysbacteriosis,is the ideal micro-ecological regulator,and its efficacy is better than Bifidobiogen-Livzon 's.