Adipsic,but not anorectic,effect of fluprazine hydrochloride in rats |
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| Authors: | Victor A. Colotla Diana Mendoza L. Matilde Valencia-Flores Maria Eugenia Dorantes Miguel Luján Efraín Campos-Sepúlveda |
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| Affiliation: | (1) Facultad de Psicología, Universidad Nacional Autónoma de México, 04510 Coyoacán, D.F., México;(2) Laboratorio de Psicobiología, Facultad de Filosofia y Ciencias de la Educación, Universidad de Sevilla, Apartado 3128, E-41004 Sevilla, Spain;(3) Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur 3877, 14410 Tlalpan, D.F., México;(4) Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Coyoacán, D.F., México;(5) 3359 Ganymede Drive, V3J 1A5 Burnaby, BC, Canada |
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| Abstract: | ![]()
The present experiment explored the anorectic and adipsic effects of fluprazine hydrochloride, a phenylpiperazine compound. Thirty-eight albino rats were randomly assigned either to a control saline group (six rats) or to groups (eight subjects each) receiving an IP dose of fluprazine in saline (1.25, 2.5, 5 or 10 mg/kg). No anorectic effect of the drug doses was observed 30, 60, 90, 120, 180 and 240 min, and 24 h after drug injection. However, water drinking was significantly decreased 30 min after drug administration, with 5 and 10 mg/kg, compared to saline. |
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| Keywords: | Phenylpiperazine Fluprazine Food intake Water intake Rats |
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