丙泊酚中/长链脂肪乳注射液与小剂量盐酸利多卡因注射液的配伍稳定性考察

目的:考察丙泊酚中/长链脂肪乳注射液与小剂量盐酸利多卡因注射液的配伍稳定性。方法:分别将盐酸利多卡因注射液0.25、0.5、1 ml(含盐酸利多卡因5、10、20 mg)加入丙泊酚中/长链脂肪乳注射液20 ml中,考察6 h内配伍溶液的外观、pH值以及两种药物的含量变化。结果:丙泊酚中/长链脂肪乳注射液中加入盐酸利多卡因注射液,6 h内利多卡因与丙泊酚含量变化均<3%,外观、pH值均无显著变化。结论:丙泊酚与小剂量的利多卡因配伍后6h内含量、外观、pH值稳定。

Compatibility Stability of Propofol Medium and Long Chain Fat Emulsion Injection Mixed with Small Dose of Lidocaine Hydrochloride Injection

OBJECTIVE： To investigate the compatiblity stability of Propofol medium and long chain fat emulsion injection mixed with small dose of Lidocaine hydrochloride injection. METHODS： Lidocaine hydrochloride injection 0.25, 0.5 and 1 ml （containing lidocaine hydrochloride 5, 10 and 20 mg） were added into 20 ml Propofol medium and long chain fat emulsion injec- tion. The appearance, pH value and content variation of mixture were investigated within 6 h. RESULTS ： The content changes of li- docaine and propofol were less than 3 % within 6 hours after the compatibility solution prepared. No significant change in appear- ance and pH value was observed. CONCLUSIONS： The appearance, pH and content of compatibility solution are stable within 6 h after the propofol mixed with small dose of lidocaine.