| 外源性一氧化氮对约氏疟原虫配子体感染力影响的初步研究 |
| |
| 引用本文： | 曹雅明,闫建中,刘英杰,张守平. 外源性一氧化氮对约氏疟原虫配子体感染力影响的初步研究[J]. 中国公共卫生, 2001, 17(7): 589-590 |
| |
| 作者姓名： | 曹雅明 闫建中 刘英杰 张守平 |
| |
| 作者单位： | 1. 中国医科大学基础医学院,
2. 沈阳市卫生防疫站 |
| |
| 摘 要： | 目的 探讨其在约氏疟原虫感染早期、外源性NO对配子体感染力及红内期虫体血症水平的影响。方法 以BLAB／c小鼠及斯氏按蚁为实验对象，观察NOC5处理前、后感染小鼠虫体血症水平和蚊血食后其胃部囊合子形成状况。结果 NOC5能够显抑制配子体对蚊的感染力，而且其抑制作用与其剂量呈正比，但未发现对疟原虫红内期虫体的明显影响。结论 外源性NO是介导约氏疟原虫配子体感染力下降的效应分子。
|
| 关 键 词： | 约氏疟原虫 虫体血症 配子体 外源性一氧化氮 |
| 文章编号： | 1001-0580(2001)07-0589-02 |
| 修稿时间： | 2001-03-27 |
Preliminary Study on Effet of Exogenous NO on Parasites During the Early Stage of Infection with plasmodium yoelii |
| |
| GAO Ya ming,et al.. Preliminary Study on Effet of Exogenous NO on Parasites During the Early Stage of Infection with plasmodium yoelii[J]. Chinese Journal of Public Health, 2001, 17(7): 589-590 |
| |
| Authors: | GAO Ya ming et al. |
| |
| Affiliation: | GAO Ya ming,et al.College of Basic Medical Sciences,China Medical University |
| |
| Abstract: | Objective To investigate the effects of exogenous NO on the gametocyte infectivity and parasitemia during the early stage of infection with plasmodium yoelii.Methods The level of parasitemia in blood from infected BALB/c mice and oocyst formation in mosquitoes-Anopheles stephensi were observed before and after dealing with NOC5.Results NO donor NOC5 could inhibit the infectivity of gametocytes to mosquitoes,whose effect had close positive relationship with the NO dosage,but it had no remarkable effect on bloodstage malaria parasites.Conclusion Exogenous NO is an effective molecule,which could inhibit the infectivity of plasmodium yoelii gametocytes to mosquitoes. |
| |
| Keywords: | plasmodium yoelii parasitimia gametocytes exogenous nitric oxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
