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| 高氟饮水对小鼠脑功能的影响 | |
| 引用本文： | 孙增荣,刘风贞,吴丽娜,吕严,于德奎. 高氟饮水对小鼠脑功能的影响[J]. 中国地方病学杂志, 2000, 19(4): 262-263 |
| 作者姓名： | 孙增荣 刘风贞 吴丽娜 吕严 于德奎 |
| 作者单位： | 天津医科大学,公共卫生学院,环境卫生教研室,天津,300070 |
| 基金项目： | 天津医科大学青年基金!资助 ( 1998) |
| 摘 要： | 目的 探讨高氟饮水对小鼠脑功能的影响。方法 对饮加氟离子浓度１００、５０、１０ｍｇ／Ｌ水６个月的小鼠，通过行为毒理学实验（穿梭箱试验）判断其学习和记忆功能，并对其脑组织胆碱酯酶（ＣｈＥ）活力进行测定。结果 饮高氟水的小鼠学习和记忆能力显著落后于对照组；高氟组小鼠脑组织ＣｈＦ活力显著高于对照组。结论 高氟饮水对小鼠脑功能有显著的影响，氟对中枢神经系统具有毒性作用。 |
| 关 键 词： | 胆碱酯酶 饮水型氟中毒 脑功能 小鼠 |
Effects of high fluoride drinking water on the cerebral functions of mice |
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| SUN Zeng-rong,LIU Feng-zhen,WU Li-na,et al. Effects of high fluoride drinking water on the cerebral functions of mice[J]. Chinese Jouranl of Endemiology, 2000, 19(4): 262-263 | |
| Authors: | SUN Zeng-rong LIU Feng-zhen WU Li-na et al |
| Abstract: | Objective To study the effects of high fluoride concentration in drinking water on the cerebral functions of mice.Methods The abilities of learning and memory of high-fluoride exposed and control groups of mice were measured by behavior-toxicological test (Shuttle box Test) and the cholinesterase (ChE) activity in brain tissue homogeate of the mice was determined.Results The abilities of learning and memory of high-fluoride exposed groups were significantly lower than that of the control group,while the brain ChE activities of high-fluoride exposed groups were significantly higher.Conclusions High fluoride concentration in drinking water could decrease the cerebral functions of mice.Fluoride is a neurotoxicant. |
| Keywords: | Fluoride Drinking water Cerebral function Cholinesterase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |