| 格列齐特分散片处方及制备工艺研究 |
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| 引用本文： | 许军,彭红,王路华,赵德芳.格列齐特分散片处方及制备工艺研究[J].时珍国医国药,2007,18(11):2671-2672. |
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| 作者姓名： | 许军 彭红 王路华 赵德芳 |
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| 作者单位： | 江西中医学院,江西,南昌,330004 |
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| 摘 要： | 目的考察及筛选格列齐特分散片的制备工艺和处方。方法通过系列实验筛选崩解剂等辅料,确定处方及制备工艺,比较了分散片及普通片剂中主药的溶出度。结果确定了以交联羧甲基纤维素钠、交联聚乙烯吡咯烷酮作为崩解剂的分散片处方;分散片溶出速率较普通片快。结论格列齐特分散片处方合理、工艺可行,符合分散片的要求。
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| 关 键 词： | 格列齐特 分散片 处方 制备工艺 |
| 文章编号： | 1008-0805（2007）11-2671-02 |
| 收稿时间： | 2007-01-30 |
| 修稿时间： | 2007-05-10 |
Optimization of Formula and Preparation Technology of Gliclazide Dispersible Tablets |
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| XU Jun,PENG Hong,WANG Lu-hua,ZHAO De-fang.Optimization of Formula and Preparation Technology of Gliclazide Dispersible Tablets[J].Lishizhen Medicine and Materia Medica Research,2007,18(11):2671-2672. |
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| Authors: | XU Jun PENG Hong WANG Lu-hua ZHAO De-fang |
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| Institution: | Department of Pharmacy, Jiangxi University of TCM,Nanchang 330004, China |
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| Abstract: | Objective To optimize the preparation technology and the formula of Gliclazide dispersible tablets.Methods The formula and preparation process were optimized by a series of experiments.The dissolution rates of the principal agent in dispersible tablets and conventional tablets were determined and compared.Results Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula;the dissolution rates of the dispersible tablets were faster than those of the conventional tablets.Conclusion The prepared gliclazide dispersible tablet is reasonable in formula,feasible in technology and it meets the quality standards. |
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| Keywords: | Gliclazide Dispersible tablets Formula Preparation technologies |
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