三种奥美拉唑胶囊健康人的生物利用度及其对胃内24小时pH值的影响

目的 比较３种奥美拉唑产品（洛赛克、奥克、奥美拉唑）４０ｍｇ在健康人的生物利用度及对胃内２４ＰＨ值的影响。方法 交叉试验设计：１８例健康志原者（男１２例,女６例）被随机分成３组,每组交叉服用洛塞克、奥克、奥美拉唑胶囊１次４０ｍｇ,交叉间隔时间７天。结果 药代动力学研究结果表明相对于奥克胶囊与奥美拉唑胶囊,洛赛克胶囊有吸收速度快、血药浓度高与持续时间长及生物利用度高的优点。胃内２４Ｐ俞 不同胶囊服用

Bioavailability of three brands of omeprazole capsule and their effects on 24 hour intragastric pH in healthy volunteers

Objective To compare the bioavailability of three brands of omeprazole capsule (Losec, Aoke Changzhou No.4 Pharm, Omeprazole Sanye Pharm) and their effects on 24 hour intragastric pH in healthy volunteers. Methods With crossover design (washout period of 7 days), 18 healthy volunteers (12 men, 6 women) were randomly divided into three groups. Each subject was given the three different brands of omeprazole capsule 40 mg respectively. Results The pharmacokinetic study revealed that Losec had an advantage over other two brands of omeprazole capsule in that it was absorbed more rapidly and to a greater extent, resulting in higher plasma concentration and longer staying time in blood. It also showed the shortest latent time in elevating intragastric pH (2.53 hours), the largest net increment in mean gastric pH (3.37), and the greatest prolongation of time with pH>4 (15.3 hours) among the three products. Conclusion The three brands of omeprazole capsule are significantly different with respect to their pharmacokintic process and effects on 24 hour intragastric pH profile. Losec is superior to other two brands of omeprazole capsule in view of its better bioavailbility, quicker onset of action, more potent and lasting antisecretory effect.