胃肠道多原发恶性肿瘤35例分析

目的 探讨胃肠道多原发恶性肿瘤的临床病理特点。方法 通过计算机病案管理系统检索我院近５年手术治疗的胃肠道恶性肿瘤８２０例，其中３５例经病理确诊为胃肠道多原发癌，发生率为４．３％。男女之比为２．５：１。结果 多原发大肠癌２５例，胃及胃肠多原发癌１０例；同时癌２３例，异时癌１２例；胃多原发癌的眼病年龄、病程、组织分化不良程度均高于大肠多原发癌及胃肠多原发癌。胃肠道多原发癌发病年龄轻，癌灶分布以右半结肠

An analysis of 35 cases of multiple gastrointestinal cancers

OBJECTIVE: To explore the clinical and pathologic features of multiple gastrointestinal cancers. METHODS: In the past 5 years 820 cases of gastric and colorectal carcinomas were surgically treated in the Nanfang hospital. Multiple primary cancers were pathologically confirmed in 35 (4.3%) of these patients. Ratio of male to female was 2.5:1. RESULTS: Of these 35 cases, there were 25 multiple colorectal cancers, 10 gastric or gastrointestinal multiple carcinomas. The cancers of 23 of the cases were synchronous and 12 metachronous. The age, interval time and degree of differentiation of the multiple gastric cancers were higher or longer than those of the multiple colorectal and gastrointestinal ones. High frequency of multiple gastrointestinal cancers in the right colon and high incidence of polyps accompanying multiple tumors were found in patients of young age. Survival rate in patients with synchronous cancer were similar to that in patients with single tumor. However patients with metachronous tumors had better prognosis than those with single cancer. CONCLUSION: Multiple cancers must be detected as early as possible. Early detection and excision may increase the 5 year survival rate.