Genetic information in the diagnosis and treatment of hypertension |
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Authors: | Maciej?Tomaszewski Lukas?Zimmerli Fadi?J?Charchar Email author" target="_blank">Anna?F?DominiczakEmail author |
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Institution: | (1) BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126, University Place, G12 8TA Glasgow, UK |
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Abstract: | Advancement in cardiovascular science should be measured by a number of new diagnostic and therapeutic options applied in
clinical practice as a result of translational research. Hypertension genetics is a good example of such a successful transfer
of knowledge from bench to bedside. There are genetic methods currently used as diagnostic tools in patients presenting with
secondary forms of hypertension, including primary hyperaldosteronism, Cushing’s syndrome, pheochromocytoma, and chronic kidney
disease. Directed treatment that corrects pathophysiologic abnormalities is available for several monogenic forms of hypertension
as a result of uncovering their underlying genetic mechanisms. Progress in hypertension pharmacogenetics and pharmacogenomics
brings closer a perspective of personalized antihypertensive treatment and gene transfer strategies, which, although still
considered as innovative approaches, may soon become options to treat, control, and, possibly, cure hypertension. |
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