| 前列腺特异性膜抗原PET/CT特异性分子显像在非前列腺癌诊断中的应用 |
| |
| 引用本文： | 刘特立,刘辰,张羽琪,邓虞娇,朱华,杨志.前列腺特异性膜抗原PET/CT特异性分子显像在非前列腺癌诊断中的应用[J].肿瘤防治研究,2019,46(11):1022-1026. |
| |
| 作者姓名： | 刘特立 刘辰 张羽琪 邓虞娇 朱华 杨志 |
| |
| 作者单位： | 1. 100142 北京，北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科 恶性肿瘤发病机制及转化研究教育部重点实验室；2. 221004 江苏，徐州医科大学临床医学院临床医学系；3. 401331 重庆，重庆医科大学第二临床学院医学影像系 |
| |
| 基金项目： | 北京市自然科学基金（7194246）；中国博士后科学基金面上资助（2018M631276）；国家自然科学基金（81571705, 81671733） |
| |
| 摘 要： | 前列腺特异性膜抗原（PSMA）是由前列腺上皮细胞分泌的一种Ⅱ型谷氨酸缩肽酶，特异性高表达于前列腺癌及其转移灶的细胞中，在多数实体瘤部位毛细血管内皮细胞中有较高程度的表达。目前，已有超过二十种PSMA靶向的分子探针用于前列腺癌的诊断与治疗。本文综述了PSMA在除前列腺癌以外的多种实体瘤中的表达情况及PSMA-PET/CT特异性探针在非前列腺癌诊断中的临床应用实例，以期拓展以PSMA为靶点的新型PET探针在肿瘤分子诊断中的临床应用。
|
| 关 键 词： | 前列腺癌特异性膜抗原 PET/CT 非前列腺癌 |
| 收稿时间： | 2019-03-20 |
Application of PSMA PET/CT Specific Molecular Imaging in Diagnosis of Non-prostateCancer |
| |
| LIU Teli,LIU Chen,ZHANG Yuqi,DENG Yujiao,ZHU Hua,YANG Zhi.Application of PSMA PET/CT Specific Molecular Imaging in Diagnosis of Non-prostateCancer[J].Cancer Research on Prevention and Treatment,2019,46(11):1022-1026. |
| |
| Authors: | LIU Teli LIU Chen ZHANG Yuqi DENG Yujiao ZHU Hua YANG Zhi |
| |
| Institution: | 1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China; 2. Department of Clinical Medicine, Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China; 3.Medical Imaging, Second Clinical College of Chongqing Medical University, Chongqing 401331, China |
| |
| Abstract: | Prostate specific membrane antigen(PSMA) is a glutamate carboxypeptidase Ⅱ secreted by the epithelial cells of prostate gland. PSMA is over-expressed in the cells of prostate cancer and metastases, and also positively expressed in the tumor-related neovascular endothelial cells. Therefore, more than twenty PSMA-targeted probes had been used for the diagnosis and therapy of prostate cancer. This article reviews the expression of PSMA in non-prostate cancer and the clinical application of PSMA-PET/CT specific probes in detecting non-prostate cancer, to expand the clinical application of novel PSMA-targeted PET probes in the diagnosis of tumors. |
| |
| Keywords: | Prostate specific membrane antigen(PSMA) PET/CT Non-prostate cancer |
|
| 点击此处可从《肿瘤防治研究》浏览原始摘要信息 |
| 点击此处可从《肿瘤防治研究》下载免费的PDF全文 |
|
