血清25(OH)维生素D与非酒精性脂肪肝肝脏脂肪含量的相关性 |
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引用本文: | 付丽坤,崔红梅,卢坤玲,邹春燕,纪桂贤,李莉,李京龙,盛丽娜,谢长顺.血清25(OH)维生素D与非酒精性脂肪肝肝脏脂肪含量的相关性[J].南方医科大学学报,2019,39(9):1118. |
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作者姓名: | 付丽坤 崔红梅 卢坤玲 邹春燕 纪桂贤 李莉 李京龙 盛丽娜 谢长顺 |
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作者单位: | 秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000;秦皇岛市第一医院消化内科,河北 秦皇岛,066000 |
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基金项目: | 秦皇岛市科学技术局科研项目;中国肝炎防治基金会天晴课题 |
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摘 要: | 目的探讨血清25(OH)维生素D与非酒精性脂肪肝(NAFLD)肝内脂肪含量的关系。方法选取2017 年6~8 月我院健
康体检及住院的NAFLD者120例,将患者分为血清25(OH)维生素D>75 nmol/L(n=25,A组),50~75 nmol/L(n=35,B组),25~
50 nmol/L(n=32,C组),<25 nmol/L(n=28,D组)。采用ELISA法检测血清25(OH)维生素D浓度,应用T1WI同/反相位测定肝内
脂肪含量。全部计量资料用均数±标准差表示,多组间比较采用方差分析及Spearman 相关分析,两两比较采用LSD-t 检验。
P<0.05表示差异有统计学意义。结果B组(28.66±6.45)%及C组(38.74±11.47)%肝脏脂肪含量高于A组(22.79±6.10)%,但差
异无统计学意义(P>0.05)。D组(54.79±5.28)%肝脏脂肪含量高于A、B、C三组,差异有统计学意义(P>0.05)。随着血清25
(OH)维生素D含量减低,肝脏脂肪含量升高,呈负相关关系(P<0.05,r=-0.125)。结论血清25(OH)维生素D越低,肝脏脂肪含
量越高,血清25(OH)维生素D有望成为NAFLD的预测指标。
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关 键 词: | 血清25(OH)维生素D 肝内脂肪含量 非酒精性脂肪性肝病 |
Correlation between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty
liver disease |
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Abstract: | Objective To investigate the relationship between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty
liver disease (NAFLD). Methods A total of 120 patients with NAFLD admitted in our hospital between June and August, 2017
were enrolled and divided into 4 groups with different serum 25 (OH) vitamin D levels: >75 nmol/L (group A, n=25), 50-75
nmol/L (group B, n=35), 25-50 nmol/L (group C, n=32), and <25 nmol/L (group D, n=28). For all the patients, serum 25 (OH)
vitamin D level was measured by ELISA, and liver fat content was determined using in-phase opposed-phase T1WI sequences.
The measurement data were compared among the 4 groups to assess the association between serum 25(OH) vitamin D level
and liver fat content. Results The liver fat content appeared to be higher in group B (28.66±6.45%) and group C (38.74±11.47%)
than in group A (22.79 ± 6.10%), but the difference was not statistically significant (P>0.05); the liver fat content in group D
(54.79 ± 5.28%) was significantly higher than that in the other 3 groups (P>0.05). Liver fat content increased significantly as
serum 25(OH) vitamin D level decreased, showing an inverse correlation between them in these patients (P<0.05, r=-0.125).
Conclusion In patients with NAFLD, a decreased serum 25(OH) vitamin D level is associated with an increased liver fat
content, suggesting the value of serum 25(OH) vitamin D as a predictor of NAFLD. |
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