综合护理干预对宫颈癌伴抑郁患者心理状态及免疫力的影响

目的探讨综合护理干预对宫颈癌伴抑郁患者心理状态及免疫力的影响。方法采用随机数字法将我院2016年12月—2017年12月间收治的152例宫颈癌伴抑郁患者分为2组,每组各76例。对照组给予常规护理,观察组给予综合护理干预。比较2组患者护理前后抑郁状况(SDS评分、SAS评分)、生活质量(GQOLI-74评分)、免疫情况(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)及血清炎性因子(TNF-α、IL-6、IL-10)水平的变化。结果护理后,2组SDS、SAS评分均明显降低(均P <0. 05),且观察组显著低于对照组(均P <0. 05)。护理后,2组CD3^+、CD4^+及CD4^+/CD8^+水平显著升高(均P <0. 05),且观察组明显高于对照组(均P <0. 05),2组CD8+水平明显降低(P <0. 05),且观察组显著低于对照组(P <0. 05)。护理后,2组躯体功能维度、社会功能维度、心理功能维度及物质生活维度评分均明显提升(均P <0. 05),且观察组显著高于对照组(均P <0. 05)。护理后,2组TNF-α、IL-6及IL-10水平均显著降低(均P <0. 05),且观察组明显低于对照组(均P <0. 05)。结论综合护理干预能够改善宫颈癌患者的抑郁状态,提高患者免疫力及生活质量,并能有效改善患者机体炎症水平。

Effect of comprehensive nursing intervention on psychological state and immunity of patients with cervical cancer and depression

Objective To investigate the effect of comprehensive nursing intervention on psychological state and immunity of patients with cervical cancer and depression. Methods A total of 152 patients with cervical cancer and depression from December 2016 to December 2017 were randomly divided into two groups, with 76 cases in each group. The control group received routine nursing and the observation group received comprehensive nursing intervention. Before and after nursing, the depression status (SDS score, SAS score), life quality (GQOLI-74 score), immune status (CD3+, CD4+, CD8+, CD4+/CD8+) and serum inflammatory factors (TNF-α, IL-6 and IL-10) of two groups were compared. Results After nursing, the SDS and SAS scores of two groups significantly reduced (all P < 0.05), and observation group was significantly lower than control group (all P < 0.05). After nursing, the levels of CD3+, CD4+and CD4+/CD8+ of two groups were significantly increased (all P < 0.05), and observation group was significantly higher than control group (all P < 0.05). The CD8+ levels of two groups were significantly reduced (P < 0.05), and observation group was significantly lower than control group (P < 0.05). After nursing, the body function dimension, social function dimension, psychological function dimension and material life dimension score of the two groups significantly increased (all P <0.05), and observation group was significantly higher than control group (all P < 0.05). The TNF-α, IL-6 and IL-10 levels of two groups significantly reduced (all P < 0.05), and observation group was significantly lower than control group (all P < 0.05). Conclusion Comprehensive nursing intervention could improve the depression status immunity, life quality and body's inflammation levels of patients with cervical cancer.