Surgical,Radiation, and Systemic Treatments of Patients With Thymic Epithelial Tumors: A Clinical Practice Guideline |
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| Affiliation: | 1. Radiation Oncology, Cancer Centre of Southeastern Ontario, Kingston General Hospital and Queen’s University, Kingston, Ontario, Canada;2. Program in Evidence-Based Care, Cancer Care Ontario, McMaster University, Hamilton, Ontario, Canada;3. Medical Oncology, Juravinski Cancer Centre, and Department of Oncology, McMaster University, Hamilton, Ontario, Canada;4. Thoracic Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada;5. Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada;6. Radiation Oncology, London Regional Cancer Centre, and Western University, London, Ontario, Canada;1. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands;2. Scientific Bureau, Dutch Institute for Clinical Auditing, Leiden, The Netherlands;3. Department of Surgery, Northwest Clinics, Alkmaar, The Netherlands;4. Department of Radiology and Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands;5. Department of Radiology and Nuclear Medicine, Haaglanden Medical Center, The Hague, The Netherlands;6. Department of Radiation Oncology, The Netherlands Cancer Institute—Antoni van Leeuwenhoek, Amsterdam, The Netherlands;7. Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands;8. Department of Surgery and Department of Cardiothoracic Surgery, Amsterdam UMC location Vrije Universiteit, Amsterdam, The Netherlands;1. Department of Thoracic Surgery, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain;2. Network of Centres for Biomedical Research in Respiratory Diseases (CIBERES) Lung Cancer Group, Terrassa, Barcelona, Spain;3. Thoracic Oncology Research Group, Baptist Cancer Center, Memphis, Tennessee;4. Multidisciplinary Thoracic Oncology Program, Baptist Cancer Center, Memphis, Tennessee;5. Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan;1. Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan;2. Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan;3. Division of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan;1. Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri;2. VA St. Louis Health Care System, St. Louis, Missouri;3. Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri;4. Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri |
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| Abstract: | ![]()
IntroductionThe aim of this guideline was to provide recommendations for the most effective therapy for patients with thymic epithelial tumors, including thymoma, thymic carcinoma, and thymic neuroendocrine tumors (NETs). This guideline is intended to be used by all health care professionals managing patients with thymic epithelial tumors.MethodsThe guideline was developed by Ontario Health (Cancer Care Ontario)’s Program in Evidence-Based Care and by the Lung Cancer Disease Site Group through a systematic review of the evidence, expert consensus, and formal internal and external reviews.ResultsEvidence-based recommendations were developed to improve the management of patients with thymic epithelial tumors. The guideline includes recommendations for surgical, radiation, and systemic treatments for patients with thymoma, thymic carcinoma, and thymic NETs separated by stage of disease using the TNM staging system. Recommendations for patients with thymic NETs were endorsed from the 2021 National Comprehensive Cancer Network Neuroendocrine and Adrenal Tumors Guideline.ConclusionsThis guideline reflects the new staging system for patients with thymoma and thymic carcinoma and includes supporting evidence from the best available studies. |
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| Keywords: | Thymic epithelial tumors Systemic therapy Chemotherapy Radiotherapy Surgery Guideline |
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