慢性肺心病患者血清NO、NOS、TNF含量的变化及意义

目的:探讨慢性肺心病患者血清NO、NOS、TNF含量的变化及意义。方法:分别应用放免法和化学法对33例慢性肺心病患者进行了血清NO、NOS和TNF含量测定并与30名正常健康人作比较。结果:慢性肺心病患者在急发期血清NO、NOS、TNF水平非常显著地高于正常人组(P<0.01),经治疗后一周其水平有所下降,但与正常人组比较,仍有显著性差异(P<0.05)。结论:检测慢性肺心病患者血清NO、NOS、TNF水平对了解病情、观察疗效和预后判断均有十分重要的临床价值。

Clinical Significance of Changes of Serum NO, NOS and TNF Levels in Patients with Chronic Pulmonary Heart Diseases

Objective To study the clinical significance of changes of serum NO, NOS and TNF levels in patients with chronic pulmonary heart disease. Methods The serum concertration of TNF was determined with radioimmunoassay (RIA) and NO, NOS contents were determined with chemical methods. in 33 cases of chronic pulmonary heart diseases as well as in 30 controls. Results Serum concentration of NO, NOS, TNF during acute phase in patients with chronic pulmonary heart diseases were significantly higher than those in controls (P<0.01). After treatment for one week, sercum NO, NOS, TNF levels were markedly decreased but remained significantly higher than those in controls (P<0.05). Conclusion Detection of serum NO, NOS and TNF levels were useful for assessment of therapeutic efficacy.