| 克拉霉素颗粒溶出度测 定简 |
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| 引用本文： | 杜亮,王国金,王维剑. 克拉霉素颗粒溶出度测 定简[J]. 中国药业, 2014, 0(5): 27-28 |
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| 作者姓名： | 杜亮 王国金 王维剑 |
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| 作者单位： | [1]中国人民解放军济南军区联勤部疾病预防控制中心,山东济南250014 [2]山东省食品药品检验所,山东济南250101 |
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| 基金项目： | 国家重大科学仪器设备开发专项,项目编号：2012YQ180132. |
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| 摘 要： | 目的 建立克拉霉素颗粒溶出度的测定方法.方法 以醋酸盐缓冲液（pH =5.0）为溶出介质,溶出30 min,采用高效液相色谱法进行测定.结果 克拉霉素质量浓度在20.60～92.68μg/mL范围内与峰面积呈良好线性关系.线性回归方程为A=1.9987C＋0.1521,r=0.999 3（n =8）.结论 该方法简单、快速、准确,适用于克拉霉素颗粒的溶出度测定.
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| 关 键 词： | 克拉霉素颗粒 溶出度 高效液相色谱法 |
Dissolution Determination of Clarithromycin Granules |
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| Du Liang,Wang Guojin,Wang Weijian. Dissolution Determination of Clarithromycin Granules[J]. China Pharmaceuticals, 2014, 0(5): 27-28 |
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| Authors: | Du Liang Wang Guojin Wang Weijian |
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| Affiliation: | 1. The Centers for Disease Contorl and Drevention, Jinan Military Logistics Department of PLA, Jinan, Shandong, China 250014; 2. Shandong Provincial Institute for Food and Drug Control, Jinan, Shandong, China 250101) |
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| Abstract: | Objective To establish a method for the dissolution determination of Clarithromycin Granules.Methods With acetate buffer solution（pH =5.0） as the dissolution medium and the dissolution time of 30 rmin,the determination was performed by high performance liquid chromatography（HPLC）.Results The linear range of clarithromycin was 20.60-92.68 μg/mL,the linear equation is A =1.998 7 C ＋ 0.152 1,r =0.999 3（n =8）.Conclusion The tnethod is simple,fast,accurate and can be applied to determine the dissolution of Clarithromycin Granules. |
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| Keywords: | Clarithromycin Granules dissolution high performance liquid chromatography |
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