HBV感染者血清标志物模式与HBVDNA的水平

目的：探讨乙型肝炎病毒（HBV）感染者血清标志物模式与HBVDNA水平的关系。方法：采用时间分辨荧光免疫定量分析法（TRFIA）和荧光定量PCR技术（FQ—PCR）分别检测542例乙型肝炎感染者血清HBVM和HBVDNA。结果：542例乙型肝炎感染者血清标本HBVM模式有10种，HBVDNA检出总阳性率83．39％（452／542），各种模式HBVDNA的阳性率存在显著差异性，高拷贝数的HBVDNA主要存在于HBeAg阳性的各种模式中，与其它模式比较有显著差异（P〈0．05）。结论：动态监测HBVM和HBVDNA含量有利于对乙肝患者的诊断及疗效提供客观依据。

Serological HBV Marker Modes and HBV DNA Levels of HBV-infected People

Objective： To analyze the relationship between modes of serological HBV makers （HB- VM） and HBV DNA levels in HBV-infected people. Methods： HBVM and HBV DNA of 542 HBV- infected persons were assayed by using time resolution fluorescence immunological analysis （TRFIA） and fluorescence quantitative PCR （FQ-PCR） techniques. Results： The general HBV DNA positive rate was 83.29%. Ten modes of HBVM were found among the 542 HBV-infected persons, and the positive rates of HBV DNA were significantly different among different modes of HBVM. Higher copy levels of serum HBV DNA occurred mainly in patients with HBeAg positive mode, and were significantly different from those of patients with other modes （ P 〈 0.05 ）. Conclusions ： The dynamic monitoring on contents of HBVM and HBV DNA could provide objective references and is helpful to the diagnosis and treatment of hepatitis B patients.