Effects of tetrahydroberberine on isoproterenol-stimulated mitochondrial45Ca uptake in rabbit myocardia |
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| Authors: | Zhou Jun Li De-xing |
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| Affiliation: | (1) Department of Pharmacology, Tongji Medical University, Wuhan;(2) Department of Pharmacology, Nanjing Medical College, Nanjing |
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| Abstract: | ![]()
Summary Cardiac mitochondria of rabbit was prepared by differential centrifugation. Tetrahydroberberine (THB) 10 μmol/L innhibited isoproterenol 1 μmol/L induced45Ca uptake in the mitochondria by 48.58 %. The inhibition is concentrationdependent and may play an important role in the protection of mitochondrial function in cardiac ischemia and reperfusion injury. |
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| Keywords: | mitochondria heart calcium metabolism isoproterenol tetrahydroberberine |
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