Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins |
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| Authors: | Robert P Lisak Joyce A Benjamins Beverly Bealmear Liljana Nedelkoska Bin Yao Susan Land Diane Studzinski |
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| Affiliation: | (1) Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48210, USA;(2) Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA;(3) Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA;(4) Applied Genomics Technology Center, 5107 Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA;(5) Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA;(6) Department of Surgery, 6C University Health Center, Wayne State University School of Medicine, 4201 St. Antoine, Detroit, MI, US 48201, USA;(7) Department of Surgery, William Beaumont Hospital, 3601 W. Thirteen Mile Rd., Royal Oak, MI 48073, USA |
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| Abstract: | ![]()
Background In multiple sclerosis, inflammatory cells are found in both active and chronic lesions, and it is increasingly clear that cytokines are involved directly and indirectly in both formation and inhibition of lesions. We propose that cytokine mixtures typical of Th1 or Th2 lymphocytes, or monocyte/macrophages each induce unique molecular changes in glial cells. |
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