不同病原菌致社区获得性肺炎患者中性粒细胞表面补体受体的变化

目的 探讨不同病原菌致社区获得性肺炎（CAP）患者中性粒细胞表面补体受体（CR）1、3含量的变化.方法 59例CAP患者通过流式细胞仪测定CR的含量,同时检测患者C反应蛋白、红细胞沉降率、白细胞计数（WBC）等水平变化情况.结果 59例CAP患者中肺炎链球菌肺炎13例,A型流感病毒肺炎13例,非典型肺炎5例（支原体肺炎3例,衣原体肺炎1例,军团菌肺炎1例）,还有28例病原不明.CR1在链球菌肺炎和病原体不明肺炎中的相对含量分别为：（19.4±9.8）、（19.3±8.8）,较A型病毒性肺炎显著升高（t=6.13、5.09,均P〈0.01）.结论 CAP患者中性粒细胞表面CR1含量是一种可以提示细菌或病毒感染的有效预测因子,可作为一种快速简便的协助临床诊疗的观察指标.

Measurement of complement receptor 1 on neutrophils in bacterial and viral pneumonia

Objective To study the different expression of complement receptors on neutrophils between bacterial and viral pneumonia. Methods Fifty-nine patients with CAP were studied prospectively. CR1 ,CR3 were measured by,using flow cytometer. ESR,CRP and WBC were also measured. Results Thirteen patients had pneumococcal pneumonia; 13 patients, A type of infuenza virus pneumonia ;5 patients, atypical pneumonia, and 28 patients, aetiologically undefined pneumonia. The mean expression of complement receptor 1 ( CR1 ) on neutrophils and aetiologically undefined pneumonia was( 19.4 ± 9.8 ) and ( 19.3 ± 8.8), which were significantly higher than those with A type of infuenza virus( t = 6.13,5.09 ,P < 0.01 ). Conclusion The expression of CR1 may be of value as an additional rapid tool in the aetiological diagnosis, bacterial or viral infection of CAP.