抗过敏治疗对改善儿童慢性鼻-鼻窦炎患者的治疗效果

目的探讨儿童慢性鼻-鼻窦炎发生的影响因素及观察抗过敏治疗慢性鼻-鼻窦炎儿童的治疗效果。方法选择2013年1月至2015年6月收治的93例慢性鼻-鼻窦炎患者,年龄5~18岁。了解患者家族过敏史、以往过敏史和与过敏反应相关的疾病或症状,所有患者进行身体检查和皮肤过敏性试验。皮试阳性患者接受抗菌药物治疗,抗组胺药物治疗(抗过敏药物),局部糖皮质激素治疗,全身性糖皮质激素治疗及手术治疗后对患者进行随访,评估患者治疗效果。结果患者平均年龄(8.3±6.7)岁,男48例(51.6%),女45例(48.4%)。皮肤过敏性试验结果显示,阳性患者73例(78.5%),其中男38例(52.1%),女35例(47.9%)。阳性患者抗过敏治疗和局部糖皮质激素资料显著改善患者治疗效果,其中抗过敏治疗患者治愈率为97.7%,局部皮质激素治疗和功能性鼻内镜鼻窦术患者治愈率为64.7%和72.3%,抗菌药物治疗不能显著改善患者治疗效果;皮试阳性患者数量与年龄呈负相关。结论慢性鼻-鼻窦炎患者过敏反应或过敏相关症状的发生率较高,过敏反应与慢性鼻-鼻窦炎的发生密切相关;抗过敏治疗和局部糖皮质激素治疗能改善慢性鼻-鼻窦炎患者的临床症状,抗过敏治疗效果优于局部糖皮质激素治疗。

Effect of anti-allergic treatment for improvement in children patients with chronic rhinosinusitis

Objective To explore the influence factors of the children patients with chronic rhinosinusitis and to observe the effect of anti‐allergic treatment in children patients with chronic rhinosinusitis .Methods A total of 93 children patients (aged 5-18 years old) with chronic rhinosinusitis from Jan .2013 to Jun .2015 were selected .The familial allergic history ,past history of allergies and allergy‐related diseases or symptoms were understand for all pa‐tients ,the physical examination and skin allergy test were conducted .The data in all cases were recorded and collect‐ed .The cases of skin test positive received the antibacterial therapy ,antihistamine medication(antiallergic drugs) ,top‐ical glucocorticoid ,systemic glucocorticoid or surgery ,and then followed up for evaluating the curative effects . Results The mean age of studied patients was (8 .3 ± 6 .7) years old ,48 males(51 .6% ) and 45 females (48 .4% ) . The skin allergy test results indicated that 73 cases(78 .5% ) were positive ,including 38(52 .1% ) males and 35 fe‐males(47 .9% ) .The antiallergic treatment and topical corticosteroids treatment significantly improved the efficacies in positive patients ,the cure rate in the patients with anti‐allergic treatment was 97 .7% ,which in the patients with topical corticosteroids treatment and functional endoscopic sinus surgery was 64 .7% and 72 .3% respectively .The antibacterial therapy could not significantly improve the curative effect;the cases number of skin test positive was negatively correlated with the age .Conclusion The occurrence rates of allergic reaction or allergy‐related symptoms in children patients with chronic rhinosinusitis are higher and the allergic reaction is closely correlated with the occur‐rence of chronic rhinosinusitis ;the anti‐allergic treatment and topical corticosteroids treatment could improve clinical symptoms in the patients with chronic rhinosinusitis ,and the efficacy of anti‐allergic treatment is superior to that of topical corticosteroids treatment .